3 citations · 3 across the 2 of their papers we have counts for
3 papers
U-DESPE: a Bayesian Utility-based methodology for dosing regimen optimization in early-phase oncology trials based on Dose-Exposure, Safety, Pharmacodynamics, Efficacy
Anaïs Andrillon, Sandrine Micallef, Moreno Ursino +2
With the development of novel therapies such as molecularly targeted agents and immunotherapy, the maximum tolerated dose paradigm that "more is better" does not necessarily hold a…
Bayesian Methods for the Analysis of Early-Phase Oncology Basket Trials with Information Borrowing across Cancer Types
Jin Jin, Marie-Karelle Riviere, Xiaodong Luo +1
Research in oncology has changed the focus from histological properties of tumors in a specific organ to a specific genomic aberration potentially shared by multiple cancer types.…
On Multi-Armed Bandit Designs for Dose-Finding Clinical Trials
Maryam Aziz, Emilie Kaufmann, Marie-Karelle Riviere
We study the problem of finding the optimal dosage in early stage clinical trials through the multi-armed bandit lens. We advocate the use of the Thompson Sampling principle, a fle…