output
20162020
most citedSame but not alike: Structure, flexibility and energetics of domains in multi-domain proteins are influenced by the presence of other domains

62 citations

6 papers

q-bio.QM2020★ 47 cited

A glance into the evolution of template-free protein structure prediction methodologies

Surbhi Dhingra, Ramanathan Sowdhamini, Frédéric Cadet +1

Prediction of protein structures using computational approaches has been explored for over two decades, paving a way for more focused research and development of algorithms in comp…

q-bio.QM2019★ 18 cited

A minimum set of stable blocks for rational design of polypeptide chains Running head: A set of stable blocks for protein rational design

Alexei Nekrasov, Ludmila Alekseeva, Rudolf A. Pogosyan +4

The aim of this work was to find a minimal set of structurally stable pentapeptides, which allows forming a polypeptide chain of a required 3D structure. To search for factors that…

q-bio.QM2019★ 25 cited

Investigation of the impact of PTMs on the protein backbone conformation

Pierrick Craveur, Tarun Narwani, Joseph Rebehmed +1

Post-Translational Modifications (PTMs) are known to play a critical role in the regulation of the protein functions. Their impact on protein structures, and their link to disorder…

q-bio.QM2019★ 43 cited

In silico prediction of protein flexibility with local structure approach

Tarun Narwani, Catherine Etchebest, Pierrick Craveur +6

Flexibility is an intrinsic essential feature of protein structures, directly linked to their functions. To this day, most of the prediction methods use the crystallographic data (…

q-bio.QM2018★ 62 cited

Same but not alike: Structure, flexibility and energetics of domains in multi-domain proteins are influenced by the presence of other domains

Sneha Vishwanath, Alexandre De Brevern, Narayanaswamy Srinivasan

The majority of the proteins encoded in the genomes of eukaryotes contain more than one domain. Reasons for high prevalence of multi-domain proteins in various organisms have been…

q-bio.QM2016★ 22 cited

Global analysis of VHHs framework regions with a structural alphabet

Floriane Noël, Alain Malpertuy, Alexandre De Brevern

The VHHs are antigen-binding region/domain of camelid heavy chain antibodies (HCAb). They have many interesting biotechnological and biomedical properties due to their small size,…