78 citations
Counting papers with at most 25 authors, so collaboration author lists do not stand in for the people here.
- University of LeedsGB20 papers
- NIHR Leeds Musculoskeletal Biomedical Research UnitGB2 papers
- Wellcome TrustGB2 papers
- Dublin City UniversityIE1 paper
- Else Kröner Fresenius Center for Digital HealthDE1 paper
- Heidelberg UniversityDE1 paper
- Jinling Institute of TechnologyCN1 paper
- Leeds General InfirmaryGB1 paper
- Mass General BrighamUS1 paper
- National Center for Tumor DiseasesDE1 paper
- Neotherix (United Kingdom)GB1 paper
- Nonwovens Innovation & Research InstituteGB1 paper
21 papers
MedicalPatchNet: A Patch-Based Self-Explainable AI Architecture for Chest X-ray Classification
Patrick Wienholt, Christiane Kuhl, Jakob Nikolas Kather +2
Deep neural networks excel in radiological image classification but frequently suffer from poor interpretability, limiting clinical acceptance. We present MedicalPatchNet, an inher…
Effect of Mammalian Tissue Source on the Molecular and Macroscopic Characteristics of UV-Cured Type I Collagen Hydrogel Networks
Charles Brooker, Giuseppe Tronci
The tissue source of type I collagen is critical to ensure scalability and regulation-friendly clinical translation of new medical device prototypes. However, the selection of a co…
An injectable, self-healing and MMP-inhibiting hyaluronic acid gel via iron coordination
Ziyu Gao, Xuebin Yang, Elena Jones +4
Regulating the activity of matrix metalloproteinases (MMPs) is a potential strategy for osteoarthritis (OA) therapy, although delivering this effect in a spatially and temporally l…
Hydrogen phosphate-mediated acellular biomineralisation within a dual crosslinked hyaluronic acid hydrogel
Ziyu Gao, Layla Hassouneh, Xuebin Yang +3
The creation of hyaluronic acid (HA)-based materials as biomineralisation scaffolds for cost-effective hard tissue regenerative therapies remains a key biomedical challenge. A non-…
Induced Periosteum-Mimicking Membrane with Cell Barrier and Multipotential Stromal Cell (MSC) Homing Functionalities
Heather E. Owston, Katrina M. Moisley, Giuseppe Tronci +3
The current management of critical size bone defects (CSBDs) remains challenging and requires multiple surgeries. To reduce the number of surgeries, wrapping a biodegradable fibrou…
Hydrolytic Degradability, Cell Tolerance and On-Demand Antibacterial Effect of Electrospun Photodynamically Active Fibres
Amy Contreras, Michael J. Raxworthy, Simon Wood +1
Photodynamically active fibres (PAFs) are a novel class of stimulus-sensitive systems capable of triggering antibiotic-free antibacterial effect on-demand when exposed to light. De…
Biomimetic peptide enriched nonwoven scaffolds promote calcium phosphate mineralisation
Robabeh Gharaei, Giuseppe Tronci, Parikshit Goswami +3
Cell-free translational strategies are needed to accelerate the repair of mineralised tissues, particularly large bone defects, using minimally invasive approaches. Regenerative bo…
In-situ crosslinked wet spun collagen triple helices with nanoscale-regulated ciprofloxacin release capability
M. Tarik Arafat, Giuseppe Tronci, David J. Wood +1
The design of antibacterial-releasing coatings or wrapping materials with controlled drug release capability is a promising strategy to minimise risks of infection and medical devi…
A redox-responsive hyaluronic acid-based hydrogel for chronic wound management
Ziyu Gao, Ben Golland, Giuseppe Tronci +1
Polymer-based hydrogels have been widely applied for chronic wound therapeutics, due to their well-acclaimed wound exudate management capability. At the same time, there is still a…
Rotation-assisted wet-spinning of UV-cured gelatin fibres and nonwovens
Jessica Rickman, Giuseppe Tronci, He Liang +1
Photoinduced network formation is an attractive strategy for designing water-insoluble gelatin fibres as medical device building blocks and for enabling late-stage property customi…
Two-layer Electrospun System Enabling Wound Exudate Management and Visual Infection Response
Mohamed Basel Bazbouz, Giuseppe Tronci
The spread of antimicrobial resistance calls for chronic wound management devices that can engage with the wound exudate and signal infection by prompt visual effects. Here, the ma…
Monomer-induced customisation of UV-cured atelocollagen hydrogel networks
He Liang, Stephen J. Russell, David J. Wood +1
The covalent functionalisation of type I atelocollagen with either 4-vinylbenzyl or methacrylamide residues is presented as a simple synthetic strategy to achieve customisable, cel…
A UV-cured nanofibrous membrane of vinylbenzylated gelatin-poly(ε-caprolactone) dimethacrylate co-network by scalable free surface electrospinning
Mohamed Basel Bazbouz, He Liang, Giuseppe Tronci
Electrospun nanofibrous membranes of natural polymers, such as gelatin, are fundamental in the design of regenerative devices. Crosslinking of electrospun fibres from gelatin is re…
A hydroxamic acid-methacrylated collagen conjugate for the modulation of inflammation-related MMP upregulation
H Liang, SJ Russell, DJ Wood +1
Medical devices with matrix metalloproteinase (MMP) modulating functionality are highly desirable to restore tissue homeostasis in critical inflammation states, such as chronic wou…
Influence of telopeptides on the structural and physical properties of polymeric and monomeric acid-soluble type I collagen
Roison Holmes, Steve Kirk, Giuseppe Tronci +2
Currently two factors hinder the use of collagen as building block of regenerative devices: the potential antigenicity, and limited mechanical strength in aqueous environment. Poly…
Thiol-ene photo-click collagen-PEG hydrogels: impact of water-soluble photoinitiators on cell viability, gelation kinetics and rheological properties
Roisin Holmes, Xuebin B Yang, Aishling Dunne +3
Thiol-ene photo-click hydrogels were prepared via step-growth polymerisation using thiol-functionalised type-I collagen and 8-arm poly(ethylene glycol) norbornene terminated (PEG-N…
Hydrolytic and lysozymic degradability of chitosan systems with heparin-mimicking pendant groups
Giuseppe Tronci, Petronela Buiga, Ahmed Alhilou +3
Chitosan (CT) is an antibacterial polysaccharide that has been investigated for drug carriers, haemostats and wound dressings. For these applications, customised CT devices can oft…
A Structurally Self-Assembled Peptide Nano-Architecture by One-Step Electrospinning
Robabeh Gharaei, Giuseppe Tronci, Robert P. W. Davies +4
Self-assembling peptides (SAPs) have shown to offer great promise in therapeutics and have the ability to undergo self-assembly and form ordered nanostructures. However SAP gels ar…
In silico modeling of the rheological properties of covalently crosslinked collagen triple helices
David A. Head, Giuseppe Tronci, Stephen J. Russell +1
Biomimetic hydrogels based on natural polymers are a promising class of biomaterial, mimicking the natural extra-cellular matrix of biological tissues and providing cues for cell a…
An investigation into the nano-/micro-architecture of electrospun poly (ε-caprolactone) and self-assembling peptide fibers
Robabeh Gharaei, Giuseppe Tronci, Robert P. Davies +2
Self-assembling peptides (SAPs) have the ability to spontaneously assemble into ordered nanostructures enabling the manufacture of "designer" nanomaterials. The reversible molecula…
Biomimetic wet-stable fibres via wet spinning and diacid-based crosslinking of collagen triple helices
M. Tarik Arafat, Giuseppe Tronci, Jie Yin +2
One of the limitations of electrospun collagen as bone-like fibrous structure is the potential collagen triple helix denaturation in the fibre state and the corresponding inadequat…