75 citations
- Medical University of ViennaAT4 papers
- Lancaster UniversityGB3 papers
- Novartis (Switzerland)CH3 papers
- Berry & Associates (United States)US2 papers
- Ludwig-Maximilians-Universität MünchenDE2 papers
- TU Dortmund UniversityDE2 papers
- AstraZeneca (Sweden)SE1 paper
- Berry Consultants, LLC (United States)US1 paper
- Berry (United States)US1 paper
- Charité - Universitätsmedizin BerlinDE1 paper
- Dortmund University of Applied Sciences and ArtsDE1 paper
- Eindhoven University of TechnologyNL1 paper
11 papers
Treatment-control comparisons in platform trials including non-concurrent controls
Marta Bofill Roig, Pavla Krotka, Katharina Hees +5
Shared controls in platform trials comprise concurrent and non-concurrent controls. For a given experimental arm, non-concurrent controls refer to data from patients allocated to t…
Impact of Record-Linkage Errors in Covid-19 Vaccine-Safety Analyses using German Health-Care Data: A Simulation Study
Robin Denz, Katharina Meiszl, Peter Ihle +5
With unprecedented speed, 192,248,678 doses of Covid-19 vaccines were administered in Germany by July 11, 2023 to combat the pandemic. Limitations of clinical trials imply that the…
Models for temporal clustering of extreme events with applications to mid-latitude winter cyclones
Christina Mathieu, Merle Mendel, Katharina Hees +1
The occurrence of extreme events like heavy precipitation or storms at a certain location often shows a clustering behaviour and is thus not described well by a Poisson process. We…
NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls
Pavla Krotka, Katharina Hees, Peter Jacko +3
Platform trials evaluate the efficacy of multiple treatments, allowing for late entry of the experimental arms and enabling efficiency gains by sharing controls. The power of indiv…
On the use of non-concurrent controls in platform trials: A scoping review
Marta Bofill Roig, Cora Burgwinkel, Ursula Garczarek +4
Platform trials gained popularity during the last few years as they increase flexibility compared to multi-arm trials by allowing new experimental arms entering when the trial alre…
On model-based time trend adjustments in platform trials with non-concurrent controls
Marta Bofill Roig, Pavla Krotka, Carl-Fredrik Burman +9
Platform trials can evaluate the efficacy of several treatments compared to a control. The number of treatments is not fixed, as arms may be added or removed as the trial progresse…