843 citations
- Consejo Superior de Investigaciones CientíficasES17 papers
- Universidad Carlos III de MadridES13 papers
- Instituto de Biocomputación y Física de Sistemas Complejos10 papers
- Universidad de ZaragozaES8 papers
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- Madrid Institute for Advanced StudiesES3 papers
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15 papers · 1 filter
Optimization of sequential therapies to maximize extinction of resistant bacteria through collateral sensitivity
Javier Molina-Hernández, José A. Cuesta, Beatriz Pascual-Escudero +2
Antimicrobial resistance (AMR) threatens global health. A promising and underexplored strategy to tackle this problem is sequential therapies exploiting collateral sensitivity (CS)…
Optimal COVID-19 vaccine prioritization by age depends critically on inter-group contacts and vaccination rates
Iker Atienza-Diez, Gabriel Rodriguez-Maroto, Saúl Ares +1
The limited availability of COVID-19 vaccines has prompted extensive research on optimal vaccination strategies. Previous studies have considered various non-pharmaceutical interve…
Non-equilibrium microbial dynamics unveil a new macroecological pattern beyond Taylor's law
José Camacho-Mateu, Aniello Lampo, Saúl Ares +1
We introduce a comprehensive analytical benchmark, relying on Fokker-Planck formalism, to study microbial dynamics in presence of both biotic and abiotic forces. In equilibrium, we…
Entropic contribution to phenotype fitness
Pablo Catalán, Juan Antonio García-Martín, Jacobo Aguirre +2
All possible phenotypes are not equally accessible to evolving populations. In fact, only phenotypes of large size, i.e. those resulting from many different genotypes, are found in…
Predictability: Can the turning point and end of an expanding epidemic be precisely forecast?
Mario Castro, Saúl Ares, José A. Cuesta +1
No, they can't. Epidemic spread is characterized by exponentially growing dynamics, which are intrinsically unpredictable. The time at which the growth in the number of infected in…
From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics
Susanna Manrubia, José A. Cuesta, Jacobo Aguirre +15
Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is arguably the next major missing piece in a fully predictive theory of evolution. We refer to t…