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q-bio.BM2025★ 9 cited
GPx4 is bound to peroxidized membranes by a hydrophobic anchor
Qingyang Hu, Hantian You, Kenan Li +2
Ferroptosis is a form of cell death discovered in recent years, induced by excessive peroxidation of phospholipids. Glutathione peroxidase 4 (GPx4) is an intracellular enzyme that…
q-bio.BM2024★ 1 cited
Latent Chemical Space Searching for Plug-in Multi-objective Molecule Generation
Ningfeng Liu, Jie Yu, Siyu Xiu +7
Molecular generation, an essential method for identifying new drug structures, has been supported by advancements in machine learning and computational technology. However, challen…