693 citations
- University of TorontoCA24 papers
- University Health NetworkCA16 papers
- Vector InstituteCA8 papers
- Health NetUS4 papers
- University of WaterlooCA4 papers
- Broad InstituteUS3 papers
- Centre National de la Recherche ScientifiqueFR3 papers
- European Molecular Biology LaboratoryDE3 papers
- KU LeuvenBE3 papers
- Leiden University Medical CenterNL3 papers
- McGill UniversityCA3 papers
- Mila - Quebec Artificial Intelligence InstituteCA3 papers
10 papers · 1 filter
Geometric and Dosimetric Validation of Deformable Image Registration for Prostate MR-guided Adaptive Radiotherapy
Victor N. Malkov, Iymad R. Mansour, Vickie Kong +8
Objective: Quantify geometric and dosimetric accuracy of a novel prostate MR-to-MR deformable image registration (DIR) approach to support MR-guided adaptive radiation therapy dose…
Modeling the impact of spatial oxygen heterogeneity on radiolytic oxygen depletion during FLASH radiotherapy
Edward Taylor, Richard P. Hill, Daniel Letourneau
It has been postulated that the delivery of radiotherapy at ultra-high dose rates ("FLASH") reduces normal tissue toxicities by depleting them of oxygen. The fraction of normal tis…
A simple mathematical model of cyclic hypoxia and its impact on hypofractionated radiotherapy
Edward Taylor
There is evidence that the population of cells that experience fluctuating oxygen levels are more radioresistant than chronically hypoxic ones and hence, this population may determ…
Domain Adaptation of Automated Treatment Planning from Computed Tomography to Magnetic Resonance
Aly Khalifa, Jeff Winter, Inmaculada Navarro +2
Objective: Machine learning (ML) based radiation treatment (RT) planning addresses the iterative and time-consuming nature of conventional inverse planning. Given the rising import…
OpenKBP-Opt: An international and reproducible evaluation of 76 knowledge-based planning pipelines
Aaron Babier, Rafid Mahmood, Binghao Zhang +56
We establish an open framework for developing plan optimization models for knowledge-based planning (KBP) in radiotherapy. Our framework includes reference plans for 100 patients w…
Simulated dose painting of hypoxic sub-volumes in pancreatic cancer stereotactic body radiotherapy
Ahmed M. Elamir, Teodor Stanescu, Andrea Shessel +15
Dose painting of hypoxic tumour sub-volumes using positron-emission tomography (PET) has been shown to improve tumour control in silico in several sites. Pancreatic cancer presents…