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20102026
most citedDirect-coupling analysis of residue co-evolution captures native contacts across many protein families

1.6k citations

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physics.bio-ph2025

Enzyme-driven phase separation

Damiano Andreghetti, Alfredo Braunstein, Luca Dall'Asta +1

The formation of polarized signaling domains on cell membranes is a fundamental example of biological pattern formation. While such patterns resemble structures from equilibrium ph…

physics.bio-ph2022★ 5 cited

Optimal metabolic strategies for microbial growth in stationary random environments

Anna Paola Muntoni, Andrea De Martino

In order to grow in any given environment, bacteria need to collect information about the medium composition and implement suitable growth strategies by adjusting their regulatory…

physics.bio-ph2017★ 36 cited

An analytic approximation of the feasible space of metabolic networks

Alfredo Braunstein, Anna Paola Muntoni, Andrea Pagnani

Assuming a steady-state condition within a cell, metabolic fluxes satisfy an under-determined linear system of stoichiometric equations. Characterizing the space of fluxes that sat…

physics.bio-ph2013★ 4 cited

Nonequilibrium dynamics of an exactly solvable Ising-like model and protein translocation

A. Pelizzola, M. Zamparo

Using an Ising-like model of protein mechanical unfolding, we introduce a diffusive dynamics on its exactly known free energy profile, reducing the nonequilibrium dynamics of the m…

physics.bio-ph2011★ 17 cited

Effects of confinement on thermal stability and folding kinetics in a simple Ising-like model

Michele Caraglio, Alessandro Pelizzola

In cellular environment, confinement and macromulecular crowding play an important role on thermal stability and folding kinetics of a protein. We have resorted to a generalized ve…