153 citations · 328 across the 12 of their papers we have counts for
12 papers
Evolution of the Ubiquitin-Activating Enzyme Uba1 (E1)
Douglas C. Allan, J. C. Phillips
Ubiquitin tags diseased proteins and initiates an enzyme conjugation cascade, which has three stages. The first-stage enzyme Uba1 (E1) has evolved only modestly from slime mold to…
Configuration Interaction of Hydropathic Waves Enables Ubiquitin Functionality
Douglas C. Allan, J. C. Phillips
Ubiquitin, discovered less than 50 years ago, tags thousands of diseased proteins for destruction. It is small (only 76 amino acids), and is found unchanged in mammals, birds, fish…
Autoantibody recognition mechanisms of MUC1
J. C. Phillips
The most cost-effective blood-based, noninvasive molecular cancer biomarkers are based on p53 epitopes and MUC1 tandem repeats. Here we use dimensionally compressed bioinformatic f…
Bioinformatic Scaling of Allosteric Interactions in Biomedical Isozymes
J. C. Phillips
Allosteric (long-range) interactions can be surprisingly strong in proteins of biomedical interest. Here we use bioinformatic scaling to connect prior results on nonsteroidal anti-…
Vaccine escape in 2013-4 and the hydropathic evolution of glycoproteins of A/H3N2 viruses
J. C. Phillips
More virulent strains of influenza virus subtypes H1N1 appeared widely in 2007 and H3N2 in 2011, and especially 2013-4, when the effectiveness of the H3N2 vaccine decreased nearly…
Frequency-Rank Correlations of Rhodopsin Mutations with Tuned Hydropathic Roughness Based on Self-Organized Criticality
J. C. Phillips
The behavior of disease-linked mutations of membrane proteins is especially simple in rhodopsin, where they are well-studied, as they are responsible for retinitis pigmentosa, RP (…