Evolution of the Ubiquitin-Activating Enzyme Uba1 (E1)

Abstract

Ubiquitin tags diseased proteins and initiates an enzyme conjugation cascade, which has three stages. The first-stage enzyme Uba1 (E1) has evolved only modestly from slime mold to humans, and is > 14 times larger than Ub. Here we use critical point thermodynamic scaling theory to connect Uba1 (E1) evolution from yeast and slime mold to fruit flies and humans to subtle changes in its amino acid sequences.

arXiv comment12 pages, 6 figures

References in corpus (3)

• Quantitative Molecular Scaling Theory of Protein Amino Acid Sequences, Structure, and Functionality
• Oxygen Channels and Fractal Wave-Particle Duality in the Evolution of Myoglobin and Neuroglobin
• Configuration Interaction of Hydropathic Waves Enables Ubiquitin Functionality

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