162 citations · 514 across the 55 of their papers we have counts for
57 papers
Evaluating Transformation Models for pCLE Mosaic Registration
Ahmed Aboelela, Johannes Barcsay, Jana Friedhof +3
Confocal Laser Endomicroscopy (CLE) provides real-time, cellular-resolution optical biopsy but has a narrow field of view, which image mosaicing can extend to provide anatomical co…
Cross-Modal MRI Ovary Segmentation in Endometriosis Using Unpaired TVUS Prototype Priors
Xingjian Kang, Lina Felsner, Dominik Perrin +5
Transvaginal ultrasound (TVUS) and magnetic resonance imaging (MRI) provide complementary information for endometriosis image analysis, yet existing studies mainly focus on single-…
Large-Scale Pre-training Enables Multimodal AI Differentiation of Radiation Necrosis from Brain Metastasis Progression on Routine MRI
Ahmed Gomaa, Annette Schwarz, Ludwig Singer +23
Background: Differentiating radiation necrosis (RN) from tumor progression after stereotactic radiosurgery (SRS) remains a critical challenge in brain metastases. While histopathol…
A Self-supervised Multimodal Deep Learning Approach to Differentiate Post-radiotherapy Progression from Pseudoprogression in Glioblastoma
Ahmed Gomaa, Yixing Huang, Pluvio Stephan +19
Accurate differentiation of pseudoprogression (PsP) from True Progression (TP) following radiotherapy (RT) in glioblastoma (GBM) patients is crucial for optimal treatment planning.…
Is Self-Supervision Enough? Benchmarking Foundation Models Against End-to-End Training for Mitotic Figure Classification
Jonathan Ganz, Jonas Ammeling, Emely Rosbach +4
Foundation models (FMs), i.e., models trained on a vast amount of typically unlabeled data, have become popular and available recently for the domain of histopathology. The key ide…
Learning-Based Autonomous Navigation, Benchmark Environments and Simulation Framework for Endovascular Interventions
Lennart Karstensen, Harry Robertshaw, Johannes Hatzl +8
Endovascular interventions are a life-saving treatment for many diseases, yet suffer from drawbacks such as radiation exposure and potential scarcity of proficient physicians. Robo…
Domain and Content Adaptive Convolutions for Cross-Domain Adenocarcinoma Segmentation
Frauke Wilm, Mathias Öttl, Marc Aubreville +1
Recent advances in computer-aided diagnosis for histopathology have been largely driven by the use of deep learning models for automated image analysis. While these networks can pe…
Leveraging image captions for selective whole slide image annotation
Jingna Qiu, Marc Aubreville, Frauke Wilm +4
Acquiring annotations for whole slide images (WSIs)-based deep learning tasks, such as creating tissue segmentation masks or detecting mitotic figures, is a laborious process due t…
On the Value of PHH3 for Mitotic Figure Detection on H&E-stained Images
Jonathan Ganz, Christian Marzahl, Jonas Ammeling +20
The count of mitotic figures (MFs) observed in hematoxylin and eosin (H&E)-stained slides is an important prognostic marker as it is a measure for tumor cell proliferation. However…
Comprehensive Multimodal Deep Learning Survival Prediction Enabled by a Transformer Architecture: A Multicenter Study in Glioblastoma
Ahmed Gomaa, Yixing Huang, Amr Hagag +16
Background: This research aims to improve glioblastoma survival prediction by integrating MR images, clinical and molecular-pathologic data in a transformer-based deep learning mod…
Analysing Diffusion Segmentation for Medical Images
Mathias Öttl, Siyuan Mei, Frauke Wilm +8
Denoising Diffusion Probabilistic models have become increasingly popular due to their ability to offer probabilistic modeling and generate diverse outputs. This versatility inspir…
Style-Extracting Diffusion Models for Semi-Supervised Histopathology Segmentation
Mathias Öttl, Frauke Wilm, Jana Steenpass +9
Deep learning-based image generation has seen significant advancements with diffusion models, notably improving the quality of generated images. Despite these developments, generat…
Re-identification from histopathology images
Jonathan Ganz, Jonas Ammeling, Samir Jabari +2
In numerous studies, deep learning algorithms have proven their potential for the analysis of histopathology images, for example, for revealing the subtypes of tumors or the primar…
Rethinking U-net Skip Connections for Biomedical Image Segmentation
Frauke Wilm, Jonas Ammeling, Mathias Öttl +3
The U-net architecture has significantly impacted deep learning-based segmentation of medical images. Through the integration of long-range skip connections, it facilitated the pre…
Deep Learning model predicts the c-Kit-11 mutational status of canine cutaneous mast cell tumors by HE stained histological slides
Chloé Puget, Jonathan Ganz, Julian Ostermaier +7
Numerous prognostic factors are currently assessed histopathologically in biopsies of canine mast cell tumors to evaluate clinical behavior. In addition, PCR analysis of the c-Kit…
Comparative Analysis of Radiomic Features and Gene Expression Profiles in Histopathology Data Using Graph Neural Networks
Luis Carlos Rivera Monroy, Leonhard Rist, Martin Eberhardt +5
This study leverages graph neural networks to integrate MELC data with Radiomic-extracted features for melanoma classification, focusing on cell-wise analysis. It assesses the effe…
Automated Volume Corrected Mitotic Index Calculation Through Annotation-Free Deep Learning using Immunohistochemistry as Reference Standard
Jonas Ammeling, Moritz Hecker, Jonathan Ganz +4
The volume-corrected mitotic index (M/V-Index) was shown to provide prognostic value in invasive breast carcinomas. However, despite its prognostic significance, it is not establis…
Few Shot Learning for the Classification of Confocal Laser Endomicroscopy Images of Head and Neck Tumors
Marc Aubreville, Zhaoya Pan, Matti Sievert +7
The surgical removal of head and neck tumors requires safe margins, which are usually confirmed intraoperatively by means of frozen sections. This method is, in itself, an oversamp…
Whole Slide Multiple Instance Learning for Predicting Axillary Lymph Node Metastasis
Glejdis Shkëmbi, Johanna P. Müller, Zhe Li +3
Breast cancer is a major concern for women's health globally, with axillary lymph node (ALN) metastasis identification being critical for prognosis evaluation and treatment guidanc…
Domain generalization across tumor types, laboratories, and species -- insights from the 2022 edition of the Mitosis Domain Generalization Challenge
Marc Aubreville, Nikolas Stathonikos, Taryn A. Donovan +27
Recognition of mitotic figures in histologic tumor specimens is highly relevant to patient outcome assessment. This task is challenging for algorithms and human experts alike, with…
Focus on Content not Noise: Improving Image Generation for Nuclei Segmentation by Suppressing Steganography in CycleGAN
Jonas Utz, Tobias Weise, Maja Schlereth +5
Annotating nuclei in microscopy images for the training of neural networks is a laborious task that requires expert knowledge and suffers from inter- and intra-rater variability, e…
Adaptive Region Selection for Active Learning in Whole Slide Image Semantic Segmentation
Jingna Qiu, Frauke Wilm, Mathias Öttl +5
The process of annotating histological gigapixel-sized whole slide images (WSIs) at the pixel level for the purpose of training a supervised segmentation model is time-consuming. R…
Multi-Scanner Canine Cutaneous Squamous Cell Carcinoma Histopathology Dataset
Frauke Wilm, Marco Fragoso, Christof A. Bertram +7
In histopathology, scanner-induced domain shifts are known to impede the performance of trained neural networks when tested on unseen data. Multi-domain pre-training or dedicated d…
Deep Learning-Based Automatic Assessment of AgNOR-scores in Histopathology Images
Jonathan Ganz, Karoline Lipnik, Jonas Ammeling +10
Nucleolar organizer regions (NORs) are parts of the DNA that are involved in RNA transcription. Due to the silver affinity of associated proteins, argyrophilic NORs (AgNORs) can be…