4 citations · 6 across the 11 of their papers we have counts for
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Collective multicellular patterns arising from cadherin-linked cytoskeletal domains
XinXin Du, Ido Lavi, Michael J. Shelley
In multicellular systems, adhesion complexes, such as those composed of E-cadherin and associated catenins, mechanically couple neighboring cells by directly linking their actin-ba…
Geometric Effects in Large Scale Intracellular Flows
Olenka Jain, Brato Chakrabarti, Reza Farhadifar +3
This work probes the role of cell geometry in orienting self-organized fluid flows in the late stage Drosophila oocyte. Recent theoretical work has shown that a model, which relies…
A first-principles geometric model for dynamics of motor-driven centrosomal asters
Yuan-Nan Young, Vicente Gomez Herrera, Helena Z. Huan +2
The centrosomal aster is a mobile cellular organelle that exerts and transmits forces necessary for nuclear migration and spindle positioning. Recent experimental and theoretical s…
Mechanics and morphology of proliferating cell collectives with self-inhibiting growth
Scott Weady, Bryce Palmer, Adam Lamson +3
We study the dynamics of proliferating cell collectives whose microscopic constituents' growth is inhibited by macroscopic growth-induced stress. Discrete particle simulations of a…
Spatio-Temporal Dynamics of Nucleo-Cytoplasmic Transport
S. Alex Rautu, Alexandra Zidovska, Michael J. Shelley
Nucleocytoplasmic transport is essential for cellular function, presenting a canonical example of rapid molecular sorting inside cells. It consists of a coordinated interplay betwe…
Self-organized intracellular twisters
Sayantan Dutta, Reza Farhadifar, Wen Lu +7
Life in complex systems, such as cities and organisms, comes to a standstill when global coordination of mass, energy, and information flows is disrupted. Global coordination is no…