9 citations · 18 across the 16 of their papers we have counts for
18 papers
Polarization of the Drosophila oocyte by active cortical exchange
Mohammadhossein Firouznia, Wen Lu, Margot Lakonishok +3
Anterior-posterior polarization in the Drosophila oocyte requires posterior localization of oskar mRNA. oskar mRNA is produced in the anteriorly situated nurse cells, moved into th…
Traveling Waves Enhance Transport during Cytoplasmic Streaming in Drosophila Oogenesis
Olenka Jain, David B. Stein, Reza Farhadifar +3
Cytoplasmic streaming is believed crucial to large developing cells, such as oocytes, where flow provides a much faster route to transport and mixing of cellular components than mo…
Growing, Buckling, and Swirling: motility from polymerization
Naveen Kumar D, Michael J. Shelley, Brato Chakrabarti
Locomotion in low-Reynolds-number environments is achieved through a remarkable diversity of strategies, from flagellar rotation and ciliary beating to large-scale body deformation…
Condensation dynamics of sticky and anchored flexible biopolymers
Adam R. Lamson, Mohammadhossein Firouznia, Michael J. Shelley
Cells regulate gene expression in part by forming DNA-protein condensates in the nucleus. While existing theories describe the equilibrium size and stability of such condensates, t…
Collective multicellular patterns arising from cadherin-linked cytoskeletal domains
XinXin Du, Ido Lavi, Michael J. Shelley
In multicellular systems, adhesion complexes, such as those composed of E-cadherin and associated catenins, mechanically couple neighboring cells by directly linking their actin-ba…
The physical consequences of sperm gigantism
Jasmin Imran Alsous, Brato Chakrabarti, Bryce Palmer +1
The male fruit fly produces ~1.8 mm long sperm, thousands of which can be stored until mating in a ~200 micron sac, the seminal vesicle. While the evolutionary pressures driving su…
Correlations, mean-field limits, and transition to the concentrated regime in motile particle suspensions
Bryce Palmer, Scott Weady, Michael O'Brien +2
Suspensions of swimming particles exhibit complex collective behaviors driven by hydrodynamic interactions, showing persistent large-scale flows and long-range correlations. While…
Geometric Effects in Large Scale Intracellular Flows
Olenka Jain, Brato Chakrabarti, Reza Farhadifar +3
This work probes the role of cell geometry in orienting self-organized fluid flows in the late stage Drosophila oocyte. Recent theoretical work has shown that a model, which relies…
A first-principles geometric model for dynamics of motor-driven centrosomal asters
Yuan-Nan Young, Vicente Gomez Herrera, Helena Z. Huan +2
The centrosomal aster is a mobile cellular organelle that exerts and transmits forces necessary for nuclear migration and spindle positioning. Recent experimental and theoretical s…
Mechanics and morphology of proliferating cell collectives with self-inhibiting growth
Scott Weady, Bryce Palmer, Adam Lamson +3
We study the dynamics of proliferating cell collectives whose microscopic constituents' growth is inhibited by macroscopic growth-induced stress. Discrete particle simulations of a…
Spatio-Temporal Dynamics of Nucleo-Cytoplasmic Transport
S. Alex Rautu, Alexandra Zidovska, Michael J. Shelley
Nucleocytoplasmic transport is essential for cellular function, presenting a canonical example of rapid molecular sorting inside cells. It consists of a coordinated interplay betwe…
Cytoplasmic stirring by active carpets
Brato Chakrabarti, Stanislav Y. Shvartsman, Michael J. Shelley
Large cells often rely on cytoplasmic flows for intracellular transport, maintaining homeostasis, and positioning cellular components. Understanding the mechanisms of these flows i…
Conformations, correlations, and instabilities of a flexible fiber in an active fluid
Scott Weady, David B. Stein, Alexandra Zidovska +1
Fluid-structure interactions between active and passive components are important for many biological systems to function. A particular example is chromatin in the cell nucleus, whe…
Learning fast, accurate, and stable closures of a kinetic theory of an active fluid
Suryanarayana Maddu, Scott Weady, Michael J. Shelley
Important classes of active matter systems can be modeled using kinetic theories. However, kinetic theories can be high dimensional and challenging to simulate. Reduced-order repre…
Self-organized intracellular twisters
Sayantan Dutta, Reza Farhadifar, Wen Lu +7
Life in complex systems, such as cities and organisms, comes to a standstill when global coordination of mass, energy, and information flows is disrupted. Global coordination is no…
Studying Interstellar Turbulence Driving Scales using the Bispectrum
Michael J. O'Brien, Blakesley Burkhart, Michael J. Shelley
We demonstrate the utility of the bispectrum, the Fourier three-point correlation function, for studying driving scales of magnetohydrodynamic (MHD) turbulence in the interstellar…
Incompressible active phases at an interface. I. Formulation and axisymmetric odd flows
Leroy L. Jia, William T. M. Irvine, Michael J. Shelley
Inspired by the recent realization of a 2D chiral fluid as an active monolayer droplet moving atop a 3D Stokesian fluid, we formulate mathematically its free-boundary dynamics. The…
A compact Eulerian representation of axisymmetric inviscid vortex sheet dynamics
Adriana I. Pesci, Raymond E. Goldstein, Michael J. Shelley
A classical problem in fluid mechanics is the motion of an axisymmetric vortex sheet evolving under the action of surface tension, surrounded by an inviscid fluid. Lagrangian descr…