2 citations · 4 across the 9 of their papers we have counts for
5 papers · 2 filters
Efficient determination of optimised multi-arm multi-stage experimental designs with control of generalised error-rates
Michael Grayling, James Wason, Adrian Mander
Primarily motivated by the drug development process, several publications have now presented methodology for the design of multi-arm multi-stage experiments with normally distribut…
A two-stage Fisher exact test for multi-arm studies with binary outcome variables
Michael Grayling, Adrian Mander, James Wason
In small sample studies with binary outcome data, use of a normal approximation for hypothesis testing can lead to substantial inflation of the type-I error-rate. Consequently, exa…
Group Sequential Crossover Trial Designs with Strong Control of the Familywise Error Rate
Michael Grayling, James Wason, Adrian Mander
Crossover designs are an extremely useful tool to investigators, whilst group sequential methods have proven highly proficient at improving the efficiency of parallel group trials.…
An optimised multi-arm multi-stage clinical trial design for unknown variance
Michael Grayling, James Wason, Adrian Mander
Multi-arm multi-stage trial designs can bring notable gains in efficiency to the drug development process. However, for normally distributed endpoints, the determination of a desig…
Blinded and unblinded sample size re-estimation procedures for stepped-wedge cluster randomized trials
Michael Grayling, Adrian Mander, James Wason
The ability to accurately estimate the sample size required by a stepped-wedge (SW) cluster randomized trial (CRT) routinely depends upon the specification of several nuisance para…