3 citations · 7 across the 12 of their papers we have counts for
14 papers
Gain-function optimisation of graphical multiple testing procedures for confirmatory clinical trials
Alexander D. V. Spiers, Michael J. Grayling, Graham M. Wheeler +1
Graphical multiple testing procedures are a flexible and transparent way to control the family-wise error rate when a confirmatory trial pursues several label claims, but they leav…
Multi-outcome trials with a generalised number of efficacious outcomes
Martin Law, Michael J. Grayling, Adrian P. Mander
Existing multi-outcome designs focus almost entirely on evaluating whether all outcomes show evidence of efficacy or whether at least one outcome shows evidence of efficacy. While…
Two-stage single-arm trials are rarely reported adequately
Michael J. Grayling, Adrian P. Mander
Purpose: Two-stage single-arm trial designs are commonly used in phase II oncology to infer treatment effects for a binary primary outcome (e.g., tumour response). It is imperative…
Optimal curtailed designs for single arm phase II clinical trials
Martin Law, Michael J. Grayling, Adrian P. Mander
In single-arm phase II oncology trials, the most popular choice of design is Simon's two-stage design, which allows early stopping at one interim analysis. However, the expected tr…
Blinded and unblinded sample size re-estimation in crossover trials balanced for period
Michael Grayling, Adrian Mander, James Wason
The determination of the sample size required by a crossover trial typically depends on the specification of one or more variance components. Uncertainty about the value of these p…
Design optimisation and post-trial analysis in group sequential stepped-wedge cluster randomised trials
Michael Grayling, David Robertson, James Wason +1
Recently, methodology was presented to facilitate the incorporation of interim analyses in stepped-wedge (SW) cluster randomised trials (CRTs). Here, we extend this previous discus…