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stat.ME2023
Evaluating the impact of outcome delay on the efficiency of two-arm group-sequential trials
Aritra Mukherjee, Michael J. Grayling, James M. S. Wason
Adaptive designs(AD) are a broad class of trial designs that allow preplanned modifications based on patient data providing improved efficiency and flexibility. However, a delay in…
stat.AP2023
Utilising high-dimensional data in randomised clinical trials: a review of methods and practice
Svetlana Cherlin, Theophile Bigirumurame, Michael J Grayling +6
Introduction: Even in effectively conducted randomised trials, the probability of a successful study remains relatively low. With recent advances in the next-generation sequencing…