45 citations · 115 across the 13 of their papers we have counts for
7 papers · 1 filter
The basal level of gene expression associated with chromatin loosening shapes Waddington landscapes and controls cell differentiation
Gilles Flouriot, Charly Jehanno, Yann Le Page +3
The baseline level of transcription, which is variable and difficult to quantify, seriously complicates the normalization of comparative transcriptomic data, but its biological imp…
A model of dynamic stability of H3K9me3 heterochromatin to explain the resistance to reprogramming of differentiated cells
Charly Jehanno, Gilles Flouriot, Pascale Le Goff +1
Despite their dynamic nature, certain chromatin marks must be maintained over the long term. This is particulary true for histone 3 lysine 9 (H3K9) trimethylation, that is involved…
Drawing a Waddington landscape to capture dynamic epigenetics
Floriane Nicol-Benoit, Pascale le Goff, Denis Michel
Epigenetics is most often reduced to chromatin marking in the current literature, whereas this notion was initially defined in a more general context. This restricted view ignores…
Conformational selection or induced fit? New insights from old principles
Denis Michel
A long standing debate in biochemistry is to determine whether the conformational changes observed during biomolecular interactions proceed through conformational selection (of pre…
The accuracy of biochemical interactions is ensured by endothermic stepwise kinetics
Denis Michel, Benjamin Boutin, Philippe Ruelle
The discerning behavior of living systems relies on accurate interactions selected from the lot of molecular collisions occurring in the cell. To ensure the reliability of interact…
A role for ATP-dependent chromatin remodeling in the hierarchical cooperativity between noninteracting transcription factors
Denis Michel
Chromatin remodeling machineries are abundant and diverse in eukaryotic cells. They have been involved in a variety of situations such as histone exchange and DNA repair, but their…
Kinetic approaches to lactose operon induction and bimodality
Denis Michel
The quasi-equilibrium approximation is acceptable when molecular interactions are fast enough compared to circuit dynamics, but is no longer allowed when cellular activities are go…