828 citations · 5k across the 89 of their papers we have counts for
3 papers · 2 filters
Fast non-autoregressive inverse folding with discrete diffusion
John J. Yang, Jason Yim, Regina Barzilay +1
Generating protein sequences that fold into a intended 3D structure is a fundamental step in de novo protein design. De facto methods utilize autoregressive generation, but this es…
Improving Protein Optimization with Smoothed Fitness Landscapes
Andrew Kirjner, Jason Yim, Raman Samusevich +4
The ability to engineer novel proteins with higher fitness for a desired property would be revolutionary for biotechnology and medicine. Modeling the combinatorially large space of…
DiffDock-PP: Rigid Protein-Protein Docking with Diffusion Models
Mohamed Amine Ketata, Cedrik Laue, Ruslan Mammadov +6
Understanding how proteins structurally interact is crucial to modern biology, with applications in drug discovery and protein design. Recent machine learning methods have formulat…