5 papers
Evolutionary Le Chatelier's Principle: Phenotypic Plasticity and Genetic Assimilation via Timescale Separation in the Price Equation
Tetsuhiro S. Hatakeyama
Phenotypic plasticity and genetic assimilation play key roles in adaptive evolution, yet their underlying mechanism has lacked a unified physical description. A major theoretical d…
Thermodynamic cost-controllability tradeoff in metabolic currency coupling
Jumpei F. Yamagishi, Tetsuhiro S. Hatakeyama
Cellular metabolism is globally regulated by various currency metabolites such as ATP, GTP, and NAD(P)H. These metabolites cycle between charged (high-energy) and uncharged (low-en…
Anti-aligning Self-propelled Model of Two Species: Emergence of Self-organized Heterogeneous Aligned and Clustered Order
Takahiro Oki, Tetsuhiro S. Hatakeyama, Seiya Nishikawa +2
Self-propelled particles with anti-aligning interactions generally do not form a polar order. However, in this Letter, we show that when multiple types of such particles coexist an…
Enzyme as Maxwell's Demon: Steady-state Deviation from Chemical Equilibrium by Enhanced Enzyme Diffusion
Shunsuke Ichii, Tetsuhiro S. Hatakeyama, Kunihiko Kaneko
Enhanced enzyme diffusion (EED), in which the diffusion coefficient of an enzyme transiently increases during catalysis, has been extensively reported experimentally. We numericall…
Global Constraint Principle for Microbial Growth Law
Jumpei F. Yamagishi, Tetsuhiro S. Hatakeyama
Monod's law is a widely accepted phenomenology for bacterial growth. Since it has the same functional form as the Michaelis--Menten equation for enzyme kinetics, cell growth is oft…