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physics.bio-ph2026
Thermodynamic cost-controllability tradeoff in metabolic currency coupling
Jumpei F. Yamagishi, Tetsuhiro S. Hatakeyama
Cellular metabolism is globally regulated by various currency metabolites such as ATP, GTP, and NAD(P)H. These metabolites cycle between charged (high-energy) and uncharged (low-en…
physics.bio-ph2025
Enzyme as Maxwell's Demon: Steady-state Deviation from Chemical Equilibrium by Enhanced Enzyme Diffusion
Shunsuke Ichii, Tetsuhiro S. Hatakeyama, Kunihiko Kaneko
Enhanced enzyme diffusion (EED), in which the diffusion coefficient of an enzyme transiently increases during catalysis, has been extensively reported experimentally. We numericall…