4 papers
Sequential sample size calculations and learning curves safeguard the robust development of a clinical prediction model for individuals
Amardeep Legha, Joie Ensor, Rebecca Whittle +7
When prospectively developing a new clinical prediction model (CPM), fixed sample size calculations are typically conducted before data collection based on sensible assumptions. Bu…
A decomposition of Fisher's information to inform sample size for developing or updating fair and precise clinical prediction models -- Part 3: continuous outcomes
Rebecca Whittle, Richard D Riley, Lucinda Archer +4
Clinical prediction models enable healthcare professionals to estimate individual outcomes using patient characteristics. Current sample size guidelines for developing or updating…
A decomposition of Fisher's information to inform sample size for developing fair and precise clinical prediction models -- Part 2: time-to-event outcomes
Richard D Riley, Gary S Collins, Lucinda Archer +9
Background: When developing a clinical prediction model using time-to-event data, previous research focuses on the sample size to minimise overfitting and precisely estimate the ov…
A decomposition of Fisher's information to inform sample size for developing fair and precise clinical prediction models -- part 1: binary outcomes
Richard D Riley, Gary S Collins, Rebecca Whittle +11
When developing a clinical prediction model, the sample size of the development dataset is a key consideration. Small sample sizes lead to greater concerns of overfitting, instabil…