27 citations · 61 across the 8 of their papers we have counts for
3 papers · 1 filter
Modelling modal gating of ion channels with hierarchical Markov models
Ivo Siekmann, Mark Fackrell, Edmund J. Crampin +1
Many ion channels spontaneously switch between different levels of activity. Although this behaviour known as modal gating has been observed for a long time it is currently not wel…
Bond Graph Modelling of Chemoelectrical Energy Transduction
Peter J. Gawthrop, Ivo Siekmann, Tatiana Kameneva +3
Energy-based bond graph modelling of biomolecular systems is extended to include chemoelectrical trans- duction thus enabling integrated thermodynamically-compliant modelling of ch…
Data-driven modelling of the inositol trisphosphate receptor (IPR) and its role in calcium induced calcium release (CICR)
Ivo Siekmann, Pengxing Cao, James Sneyd +1
We give a review of the current state of the art of data-driven modelling of the inositol trisphosphate receptor (IPR). After explaining that the IPR plays a crucial role as a cent…