27 citations · 61 across the 8 of their papers we have counts for
9 papers
Reliable model selection in the presence of parameter non-identifiability
Yong See Foo, Torkel E. Loman, Alexander P. Browning +3
Mathematical models are invaluable for understanding and predicting how biological systems behave, although their construction requires specifying mechanisms and relationships that…
Mathematical modelling indicates that lower activity of the haemostatic system in neonates is primarily due to lower prothrombin concentration
Ivo Siekmann, Stefan Bjelosevic, Kerry Landman +3
Haemostasis is governed by a highly complex system of interacting proteins. Due to the central role of thrombin, thrombin generation and specifically the thrombin generation curve…
An applied mathematician's perspective on Rosennean Complexity
Ivo Siekmann
The theoretical biologist Robert Rosen developed a highly original approach for investigating the question "What is life?", the most fundamental problem of biology. Considering tha…
Invasion patterns in competitive systems
Ivo Siekmann, Michael Bengfort, Horst Malchow
Stochastic reaction-diffusion equations are a popular modelling approach for studying interacting populations in a heterogeneous environment under the influence of environmental fl…
Invasive competition with Fokker-Planck diffusion and noise
Michael Bengfort, Ivo Siekmann, Horst Malchow
Defeat and success of the competitive invasion of a populated area is described with a standard Lotka-Volterra competition model. The resident is adapted to the heterogeneous livin…
Modelling modal gating of ion channels with hierarchical Markov models
Ivo Siekmann, Mark Fackrell, Edmund J. Crampin +1
Many ion channels spontaneously switch between different levels of activity. Although this behaviour known as modal gating has been observed for a long time it is currently not wel…
Bond Graph Modelling of Chemoelectrical Energy Transduction
Peter J. Gawthrop, Ivo Siekmann, Tatiana Kameneva +3
Energy-based bond graph modelling of biomolecular systems is extended to include chemoelectrical trans- duction thus enabling integrated thermodynamically-compliant modelling of ch…
Competition of residents and invaders in a variable environment: Response to enemies and dangerous noise
Ivo Siekmann, Horst Malchow
The possible control of competitive invasion by infection of the invader and multiplicative noise is studied. The basic model is the Lotka-Volterra competition system with emergent…
Data-driven modelling of the inositol trisphosphate receptor (IPR) and its role in calcium induced calcium release (CICR)
Ivo Siekmann, Pengxing Cao, James Sneyd +1
We give a review of the current state of the art of data-driven modelling of the inositol trisphosphate receptor (IPR). After explaining that the IPR plays a crucial role as a cent…