308 citations · 1.5k across the 30 of their papers we have counts for
8 papers · 1 filter
Collective durotaxis of cohesive cell clusters on a stiffness gradient
Irina Pi-Jaumà, Ricard Alert, Jaume Casademunt
Many types of motile cells perform durotaxis, namely, directed migration following gradients of substrate stiffness. Recent experiments have revealed that cell monolayers can migra…
Role of Substrate Stiffness in Tissue Spreading: Wetting Transition and Tissue Durotaxis
Ricard Alert, Jaume Casademunt
Living tissues undergo wetting transitions: On a surface, they can either form a droplet-like cell aggregate or spread as a monolayer of migrating cells. Tissue wetting depends not…
Active Fingering Instability in Tissue Spreading
Ricard Alert, Carles Blanch-Mercader, Jaume Casademunt
During the spreading of epithelial tissues, the advancing tissue front often develops fingerlike protrusions. Their resemblance to traditional viscous fingering patterns in driven…
Active wetting of epithelial tissues
Carlos Pérez-González, Ricard Alert, Carles Blanch-Mercader +5
Development, regeneration and cancer involve drastic transitions in tissue morphology. In analogy with the behavior of inert fluids, some of these transitions have been interpreted…
Fluidization and Active Thinning by Molecular Kinetics in Active Gels
David Oriola, Ricard Alert, Jaume Casademunt
We derive the constitutive equations of an active polar gel from a model for the dynamics of elastic molecules that link polar elements. Molecular binding kinetics induces the flui…
Nonlinear amplitude dynamics in flagellar beating
David Oriola, Hermes Gadêlha, Jaume Casademunt
The physical basis of flagellar and ciliary beating is a major problem in biology which is still far from completely understood. The fundamental cytoskeleton structure of cilia and…
Bleb Nucleation through Membrane Peeling
Ricard Alert, Jaume Casademunt
We study the nucleation of blebs, i.e., protrusions arising from a local detachment of the membrane from the cortex of a cell. Based on a simple model of elastic linkers with force…
Model for probing membrane-cortex adhesion by micropipette aspiration and fluctuation spectroscopy
Ricard Alert, Jaume Casademunt, Jan Brugués +1
We propose a model for membrane-cortex adhesion which couples membrane deformations, hydrodynamics and kinetics of membrane-cortex ligands. In its simplest form, the model gives ex…