246 citations · 384 across the 27 of their papers we have counts for
5 papers · 1 filter
Sample Size Estimation using a Latent Variable Model for Mixed Outcome Co-Primary, Multiple Primary and Composite Endpoints
Martina McMenamin, Jessica K. Barrett, Anna Berglind +1
Mixed outcome endpoints that combine multiple continuous and discrete components to form co-primary, multiple primary or composite endpoints are often employed as primary outcome m…
Bayesian design and analysis of external pilot trials for complex interventions
Duncan T. Wilson, James M. S. Wason, Julia Brown +2
External pilot trials of complex interventions are used to help determine if and how a confirmatory trial should be undertaken, providing estimates of parameters such as recruitmen…
Borrowing of information across patient subgroups in a basket trial based on distributional discrepancy
Haiyan Zheng, James M. S. Wason
Basket trials have emerged as a new class of efficient approaches in oncology to evaluate a new treatment in several patient subgroups simultaneously. In this paper, we extend the…
A web application for the design of multi-arm clinical trials
Michael J Grayling, James MS Wason
Multi-arm designs provide an effective means of evaluating several treatments within the same clinical trial. Given the large number of treatments now available for testing in many…
Employing latent variable models to improve efficiency in composite endpoint analysis
Martina McMenamin, Jessica K. Barrett, Anna Berglind +1
Composite endpoints that combine multiple outcomes on different scales are common in clinical trials, particularly in chronic conditions. In many of these cases, patients will have…