2 papers
q-bio.QM2025
Heterogeneous immune recovery after viral response through a dynamical model of feedback-driven persistence and clearance
Xiaoxin Wang, Kai Kang, Leyi Zhang +1
Viral infections trigger complex immune responses with heterogeneous outcomes shaped by nonlinear feedbacks. An ordinary differential equation model is developed to investigate imm…
q-bio.OT2025
Conditional Success of Adaptive Therapy: The Role of Treatment-Holiday Thresholds and Non-Existence of Optimal Strategies Revealed by Mathematical Modelling and Optimal Control
Lanfei Sun, Haifeng Zhang, Kai Kang +5
Adaptive therapy improves cancer treatment by controlling the competition between sensitive and resistant cells through treatment holidays. This study highlights the critical role…