81 citations · 548 across the 29 of their papers we have counts for
29 papers
Insights into the role of dynamical features in protein complex formation: the case of SARS-CoV-2 spike binding with ACE2
Greta Grassmann, Mattia Miotto, Francesca Alessandrini +4
The functionality of protein-protein complexes is closely tied to the strength of their interactions, making the evaluation of binding affinity a central focus in structural biolog…
SOME Special Solutions of a Nonlinear System of 4 Ordinary Differential Equations Recently Introduced to Investigate the Evolution of Human Respiratory Virus Epidemics
Francesco Calogero, Andrea Giansanti, Farrin Payandeh
A system of 4 nonlinearly-coupled Ordinary Differential Equations has been recently introduced to investigate the evolution of human respiratory virus epidemics. In this paper we p…
Fluctuation-response theorem for Kullback-Leibler divergences to quantify causation
Andrea Auconi, Benjamin M. Friedrich, Andrea Giansanti
We define a new measure of causation from a fluctuation-response theorem for Kullback-Leibler divergences, based on the information-theoretic cost of perturbations. This informatio…
Co-evolution between Codon Usage and Protein-Protein Interaction in Bacteria
Maddalena Dilucca, Giulio Cimini, Sergio Forcelloni +1
We study the correlation between the codon usage bias of genetic sequences and the network features of protein-protein interaction (PPI) in bacterial species. We use PCA techniques…
A fluctuation theorem for time-series of signal-response models with the backward transfer entropy
Andrea Auconi, Andrea Giansanti, Edda Klipp
The irreversibility of trajectories in stochastic dynamical systems is linked to the structure of their causal representation in terms of Bayesian networks. We consider stochastic…
Bacterial protein interaction networks: connectivity is ruled by gene conservation, essentiality and function
Maddalena Dilucca, Giulio Cimini, Andrea Giansanti
Protein-protein interaction (PPI) networks are the backbone of all processes in living cells. In this work we relate conservation, essentiality and functional repertoire of a gene…