491 citations · 3.8k across the 67 of their papers we have counts for
10 papers · 1 filter
Stable developmental patterns of gene expression without morphogen gradients
Maciej Majka, Nils B. Becker, Pieter Rein ten Wolde +2
Gene expression patterns (GEPs) are established by cross-regulating target genes that interpret morphogen gradients. However, as development progresses, morphogen activity is reduc…
Synchronous replication initiation of multiple origins
Mareike Berger, Pieter Rein ten Wolde
Initiating replication synchronously at multiple origins of replication allows the bacterium Escherichia coli to divide even faster than the time it takes to replicate the entire c…
Trade-offs between cost and information in cellular prediction
Age J. Tjalma, Vahe Galstyan, Jeroen Goedhart +3
Living cells can leverage correlations in environmental fluctuations to predict the future environment and mount a response ahead of time. To this end, cells need to encode the pas…
Constriction of actin rings by passive crosslinkers
Alexander Cumberworth, Pieter Rein ten Wolde
In many organisms, cell division is driven by the constriction of a cytokinetic ring, which consists of actin filaments and crosslinking proteins. While it has long been believed t…
Robust replication initiation from coupled homeostatic mechanisms
Mareike Berger, Pieter Rein ten Wolde
The bacterium Escherichia coli initiates replication once per cell cycle at a precise volume per origin and adds an on average constant volume between successive initiation events,…
Energetic constraints on filament mediated cell polarization
Harmen Wierenga, Pieter Rein ten Wolde
Cell polarization underlies many cellular processes, such as differentiation, migration, and budding. Many living cells, such as budding yeast and fission yeast, use cytoskeletal s…
Quantifying fluctuations in reversible enzymatic cycles and clocks
Harmen Wierenga, Pieter Rein ten Wolde, Nils B. Becker
Biochemical reactions are fundamentally noisy at a molecular scale. This limits the precision of reaction networks, but also allows fluctuation measurements which may reveal the st…
Optimal entrainment of circadian clocks in the presence of noise
Michele Monti, David K. Lubensky, Pieter Rein ten Wolde
Circadian clocks are biochemical oscillators that allow organisms to estimate the time of the day. These oscillators are inherently noisy due to the discrete nature of the reactant…
A Thermodynamically consistent model of the post-translational Kai circadian clock
Joris Paijmans, David K Lubensky, Pieter Rein ten Wolde
The principal pacemaker of the circadian clock of the cyanobacterium S. elongatus is a protein phosphorylation cycle consisting of three proteins, KaiA, KaiB and KaiC. KaiC forms a…
Period Robustness and Entrainability of the Kai System to Changing Nucleotide Concentrations
Joris Paijmans, David K Lubensky, Pieter Rein ten Wolde
Circadian clocks must be able to entrain to time-varying signals to keep their oscillations in phase with the day-night rhythm. On the other hand, they must also exhibit input comp…