5 papers
LEME: Open Large Language Models for Ophthalmology with Advanced Reasoning and Clinical Validation
Hyunjae Kim, Xuguang Ai, Sahana Srinivasan +27
The rising prevalence of eye diseases poses a growing public health burden. Large language models (LLMs) offer a promising path to reduce documentation workload and support clinica…
Performance of GPT-5 Frontier Models in Ophthalmology Question Answering
Fares Antaki, David Mikhail, Daniel Milad +11
Large language models (LLMs) such as GPT-5 integrate advanced reasoning capabilities that may improve performance on complex medical question-answering tasks. For this latest gener…
Benchmarking Next-Generation Reasoning-Focused Large Language Models in Ophthalmology: A Head-to-Head Evaluation on 5,888 Items
Minjie Zou, Sahana Srinivasan, Thaddaeus Wai Soon Lo +13
Recent advances in reasoning-focused large language models (LLMs) mark a shift from general LLMs toward models designed for complex decision-making, a crucial aspect in medicine. H…
LMOD: A Large Multimodal Ophthalmology Dataset and Benchmark for Large Vision-Language Models
Zhenyue Qin, Yu Yin, Dylan Campbell +6
The prevalence of vision-threatening eye diseases is a significant global burden, with many cases remaining undiagnosed or diagnosed too late for effective treatment. Large vision-…
Can OpenAI o1 Reason Well in Ophthalmology? A 6,990-Question Head-to-Head Evaluation Study
Sahana Srinivasan, Xuguang Ai, Minjie Zou +14
Question: What is the performance and reasoning ability of OpenAI o1 compared to other large language models in addressing ophthalmology-specific questions? Findings: This study ev…