activity
20102026
most citedCommon lines modeling for reference free ab-initio reconstruction in cryo-EM

30 citations · 101 across the 28 of their papers we have counts for

collaborators

32 papers

cs.DC2026

nvPAX: Constrained Optimization for Dynamic Power Allocation in Hierarchical and Multi-Tenant Systems

Hadar Sivan, Gil Shabat, Yoel Shkolnisky

Power oversubscription is increasingly central to datacenter operation as power density grows, making it necessary to dynamically allocate limited power budgets across devices base…

q-bio.QM2026

SHREC: A Spectral Embedding-Based Approach for Ab-Initio Reconstruction of Helical Molecules

Guy Shapira, Yoel Shkolnisky

Cryo-electron microscopy (cryo-EM) has emerged as a powerful technique for determining the three-dimensional structures of biological molecules at near-atomic resolution. However,…

stat.ML2026

SOLVAR: Fast covariance-based heterogeneity analysis with pose refinement for cryo-EM

Roey Yadgar, Roy R. Lederman, Yoel Shkolnisky

Cryo-electron microscopy (cryo-EM) has emerged as a powerful technique for resolving the three-dimensional structures of macromolecules. A key challenge in cryo-EM is characterizin…

math.ST2024★ 2 cited

Object detection under the linear subspace model with application to cryo-EM images

Amitay Eldar, Keren Mor Waknin, Samuel Davenport +3

Detecting multiple unknown objects in noisy data is a key problem in many scientific fields, such as electron microscopy imaging. A common model for the unknown objects is the line…

cs.LG2023

G-invariant diffusion maps

Eitan Rosen, Xiuyuan Cheng, Yoel Shkolnisky

The diffusion maps embedding of data lying on a manifold has shown success in tasks such as dimensionality reduction, clustering, and data visualization. In this work, we consider…

cs.LG2023

The G-invariant graph Laplacian

Eitan Rosen, Paulina Hoyos, Xiuyuan Cheng +2

Graph Laplacian based algorithms for data lying on a manifold have been proven effective for tasks such as dimensionality reduction, clustering, and denoising. In this work, we con…

eess.IV2022

Signal enhancement for two-dimensional cryo-EM data processing

Guy Sharon, Yoel Shkolnisky, Tamir Bendory

Different tasks in the computational pipeline of single-particle cryo-electron microscopy (cryo-EM) require enhancing the quality of the highly noisy raw images. To this end, we de…

physics.comp-ph2022

A common lines approach for ab-initio modeling of molecules with tetrahedral and octahedral symmetry

Adi Shasha Geva, Yoel Shkolnisky

A main task in cryo-electron microscopy single particle reconstruction is to find a three-dimensional model of a molecule given a set of its randomly oriented and positioned noisy…

eess.IV2022

Three-Dimensional Alignment of Density Maps in Cryo-Electron Microscopy

Yael Harpaz, Yoel Shkolnisky

A common task in cryo-electron microscopy (cryo-EM) data processing is to compare three-dimensional density maps of macromolecules. In this paper, we propose an algorithm for align…

cs.CV2022

ASOCEM: Automatic Segmentation Of Contaminations in cryo-EM

Amitay Eldar, Ido Amos, Yoel Shkolnisky

Particle picking is currently a critical step in the cryo-electron microscopy single particle reconstruction pipeline. Contaminations in the acquired micrographs severely degrade t…

cs.LG2020★ 2 cited

A Perturbation-Based Kernel Approximation Framework

Roy Mitz, Yoel Shkolnisky

Kernel methods are powerful tools in various data analysis tasks. Yet, in many cases, their time and space complexity render them impractical for large datasets. Various kernel app…

physics.ins-det2020

Super-resolution SAXS based on PSF engineering and sub-pixel detector translations

Benjamin Gutman, Michael Mrejen, Gil Shabat +3

Small-angle X-ray scattering (SAXS) technique enables convenient nanoscopic characterization for various systems and conditions. Nonetheless, lab-based SAXS systems intrinsically s…

physics.data-an2019

KLT Picker: Particle Picking Using Data-Driven Optimal Templates

Amitay Eldar, Boris Landa, Yoel Shkolnisky

Particle picking is currently a critical step in the cryo-EM single particle reconstruction pipeline. Despite extensive work on this problem, for many data sets it is still challen…

cs.LG2019

ROIPCA: An online memory-restricted PCA algorithm based on rank-one updates

Roy Mitz, Yoel Shkolnisky

Principal components analysis (PCA) is a fundamental algorithm in data analysis. Its memory-restricted online versions are useful in many modern applications, where the data are to…

math.ST2019

Rank-one Multi-Reference Factor Analysis

Yariv Aizenbud, Boris Landa, Yoel Shkolnisky

In recent years, there is a growing need for processing methods aimed at extracting useful information from large datasets. In many cases the challenge is to discover a low-dimensi…

math.ST2019★ 4 cited

Multi-reference factor analysis: low-rank covariance estimation under unknown translations

Boris Landa, Yoel Shkolnisky

We consider the problem of estimating the covariance matrix of a random signal observed through unknown translations (modeled by cyclic shifts) and corrupted by noise. Solving this…

eess.IV2019★ 5 cited

Common lines ab-initio reconstruction of -symmetric molecules

Eitan Rosen, Yoel Shkolnisky

Cryo-electron microscopy is a state-of-the-art method for determining high-resolution three-dimensional models of molecules, from their two-dimensional projection images taken by a…

cs.CG2019★ 13 cited

A common lines approach for ab-initio modeling of cyclically-symmetric molecules

Gabi Pragier, Yoel Shkolnisky

One of the challenges in single particle reconstruction in cryo-electron microscopy is to find a three-dimensional model of a molecule using its two-dimensional noisy projection-im…

math.NA2018★ 2 cited

Sampling and Approximation of Bandlimited Volumetric Data

Rami Katz, Yoel Shkolnisky

We present an approximation scheme for functions in three dimensions, that requires only their samples on the Cartesian grid, under the assumption that the functions are sufficient…

q-bio.QM2018★ 30 cited

Common lines modeling for reference free ab-initio reconstruction in cryo-EM

Ido Greenberg, Yoel Shkolnisky

We consider the problem of estimating an unbiased and reference-free ab-inito model for non-symmetric molecules from images generated by single-particle cryo-electron microscopy. T…

cs.CV2018

The steerable graph Laplacian and its application to filtering image data-sets

Boris Landa, Yoel Shkolnisky

In recent years, improvements in various image acquisition techniques gave rise to the need for adaptive processing methods, aimed particularly for large datasets corrupted by nois…

math.NA2017

Symmetric rank-one updates from partial spectrum with an application to out-of-sample extension

Roy Mitz, Nir Sharon, Yoel Shkolnisky

Rank-one update of the spectrum of a matrix is a fundamental problem in classical perturbation theory. In this paper, we consider its variant where only part of the spectrum is kno…

cs.CV2016

A max-cut approach to heterogeneity in cryo-electron microscopy

Yariv Aizenbud, Yoel Shkolnisky

The field of cryo-electron microscopy has made astounding advancements in the past few years, mainly due to advancements in electron detectors' technology. Yet, one of the key open…

cs.CV2016★ 23 cited

Steerable Principal Components for Space-Frequency Localized Images

Boris Landa, Yoel Shkolnisky

This paper describes a fast and accurate method for obtaining steerable principal components from a large dataset of images, assuming the images are well localized in space and fre…