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20162022
most citedThe use of external controls: To what extent can it currently be recommended?

88 citations · 133 across the 5 of their papers we have counts for

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q-bio.QM2016

Systematic reviews in paediatric multiple sclerosis and Creutzfeldt-Jakob disease exemplify shortcomings in methods used to evaluate therapies in rare conditions

Steffen Unkel, Christian Röver, Nigel Stallard +4

BACKGROUND: Randomized controlled trials (RCTs) are the gold standard design of clinical research to assess interventions. However, RCTs cannot always be applied for practical or e…