813 citations · 1.3k across the 10 of their papers we have counts for
8 papers · 1 filter
Network strategies to understand the aging process and help age-related drug design
Gabor I. Simko, David Gyurko, Daniel V. Veres +2
Recent studies have demonstrated that network approaches are highly appropriate tools to understand the extreme complexity of the aging process. The generality of the network conce…
Drug-therapy networks and the predictions of novel drug targets
Zoltan Spiro, Istvan A. Kovacs, Peter Csermely
Recently, a number of drug-therapy, disease, drug, and drug-target networks have been introduced. Here we suggest novel methods for network-based prediction of novel drug targets a…
Chaperones as integrators of cellular networks: Changes of cellular integrity in stress and diseases
Robin Palotai, Mate S. Szalay, Peter Csermely
Cellular networks undergo rearrangements during stress and diseases. In un-stressed state the yeast protein-protein interaction network (interactome) is highly compact, and the cen…
How to design multi-target drugs: Target search options in cellular networks
Tamas Korcsmaros, Mate S. Szalay, Csaba Bode +2
Despite improved rational drug design and a remarkable progress in genomic, proteomic and high-throughput screening methods, the number of novel, single-target drugs fell much behi…
Stress-induced rearrangements of cellular networks: consequences for protection and drug design
Mate S. Szalay, Istvan A. Kovacs, Tamas Korcsmaros +2
The complexity of the cells can be described and understood by a number of networks such as protein-protein interaction, cytoskeletal, organelle, signalling, gene transcription and…
Molecular chaperones: The modular evolution of cellular networks
Tamas Korcsmaros, Istvan A. Kovacs, Mate S. Szalay +1
Molecular chaperones play a prominent role in signaling and transcriptional regulatory networks of the cell. Recent advances uncovered that chaperones act as genetic buffers stabil…