96 citations · 140 across the 6 of their papers we have counts for
6 papers · 1 filter
Generic Mechanism of Emergence of Amyloid Protofilaments from Disordered Oligomeric aggregates
Stefan Auer, Filip Meersman, Christopher M. Dobson +1
The presence of oligomeric aggregates, which is often observed during the process of amyloid formation, has recently attracted much attention since it has been associated with neur…
Self-Templated Nucleation in Peptide and Protein aggregation
Stefan Auer, Christopher M. Dobson, Michele Vendruscolo +1
Peptides and proteins exhibit a common tendency to assemble into highly ordered fibrillar aggregates, whose formation proceeds in a nucleation-dependent manner that is often preced…
Looking at structure, stability, and evolution of proteins through the principal eigenvector of contact matrices and hydrophobicity profiles
Ugo Bastolla, Markus Porto, H. Eduardo Roman +1
We review and further develop an analytical model that describes how thermodynamic constraints on the stability of the native state influence protein evolution in a site-specific m…
Prediction of site-specific amino acid distributions and limits of divergent evolutionary changes in protein sequences
Markus Porto, H. Eduardo Roman, Michele Vendruscolo +1
We derive an analytic expression for site-specific stationary distributions of amino acids from the Structurally Constrained Neutral (SCN) model of protein evolution with conservat…
The principal eigenvector of contact matrices and hydrophobicity profiles in proteins
Ugo Bastolla, Markus Porto, H. Eduardo Roman +1
With the aim to study the relationship between protein sequences and their native structures, we adopt vectorial representations for both sequence and structure. The structural rep…
Inhibition of protein crystallization by evolutionary negative design
Jonathan P. K. Doye, Ard A. Louis, Michele Vendruscolo
In this perspective we address the question: why are proteins seemingly so hard to crystallize? We suggest that this is because of evolutionary negative design, i.e. proteins have…