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physics.bio-ph2019
Mechanics of allostery: contrasting the induced fit and population shift scenarios
Riccardo Ravasio, Solange Flatt, Le Yan +3
In allosteric proteins, binding a ligand can affect function at a distant location, for example by changing the binding affinity of a substrate at the active site. The induced fit…
physics.bio-ph2018
Multicellular rosettes drive fluid-solid transition in epithelial tissues
Le Yan, Dapeng Bi
Models for confluent biological tissues often describe the network formed by cells as a triple-junction network, similar to foams. However, higher order vertices or multicellular r…