64 citations · 183 across the 5 of their papers we have counts for
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q-bio.MN2019★ 4 cited
Kinetic foundation of the zero-inflated negative binomial model for single-cell RNA sequencing data
Chen Jia
Single-cell RNA sequencing data have complex features such as dropout events, over-dispersion, and high-magnitude outliers, resulting in complicated probability distributions of mR…
q-bio.MN2019★ 57 cited
Single-cell stochastic gene expression kinetics with coupled positive-plus-negative feedback
Chen Jia, Le Yi Wang, George G. Yin +1
Here we investigate single-cell stochastic gene expression kinetics in a minimal coupled gene circuit with positive-plus-negative feedback. A triphasic stochastic bifurcation upon…
math.PR2019
Limit theorems for generalized density-dependent Markov chains and bursty stochastic gene regulatory networks
Xian Chen, Chen Jia
Stochastic gene regulatory networks with bursting dynamics can be modeled mesocopically as a generalized density-dependent Markov chain (GDDMC) or macroscopically as a piecewise-de…