144 citations · 810 across the 34 of their papers we have counts for
6 papers · 1 filter
Applications and Challenges of Machine Learning to Enable Realistic Cellular Simulations
Ritvik Vasan, Meagan P. Rowan, Christopher T. Lee +3
In this perspective, we examine three key aspects of an end-to-end pipeline for realistic cellular simulations: reconstruction and segmentation of cellular structures; generation o…
An Open Source Mesh Generation Platform for Biophysical Modeling Using Realistic Cellular Geometries
Christopher T. Lee, Justin G. Laughlin, John B. Moody +4
Advances in imaging methods such as electron microscopy, tomography and other modalities are enabling high-resolution reconstructions of cellular and organelle geometries. Such adv…
Stability Analysis of a Bulk-Surface Reaction Model for Membrane-Protein Clustering
L. M. Stolerman, M. Getz, S. G. Llewellyn Smith +2
Protein aggregation on the plasma membrane (PM) is of critical importance to many cellular processes such as cell adhesion, endocytosis, fibrillar conformation, and vesicle transpo…
A mechanical model reveals that non-axisymmetric buckling lowers the energy barrier associated with membrane neck constriction
Ritvik Vasan, Shiva Rudraraju, Matthew Akamatsu +2
Membrane neck formation is essential for scission, which, as recent experiments on tubules have demonstrated, can be location dependent. The diversity of biological machinery that…
Biophysics at the coffee shop: lessons learned working with George Oster
Oleg Igoshin, Jing Chen, Jianhua Xing +9
Over the past 50 years, the use of mathematical models, derived from physical reasoning, to describe molecular and cellular systems has evolved from an art of the few to a cornerst…
3D mesh processing using GAMer 2 to enable reaction-diffusion simulations in realistic cellular geometries
Christopher T. Lee, Justin G. Laughlin, Nils Angliviel de La Beaumelle +5
Recent advances in electron microscopy have enabled the imaging of single cells in 3D at nanometer length scale resolutions. An uncharted frontier for in silico biology is the abil…