3 papers
physics.comp-ph2019
An Open Source Mesh Generation Platform for Biophysical Modeling Using Realistic Cellular Geometries
Christopher T. Lee, Justin G. Laughlin, John B. Moody +4
Advances in imaging methods such as electron microscopy, tomography and other modalities are enabling high-resolution reconstructions of cellular and organelle geometries. Such adv…
q-bio.QM2019
3D mesh processing using GAMer 2 to enable reaction-diffusion simulations in realistic cellular geometries
Christopher T. Lee, Justin G. Laughlin, Nils Angliviel de La Beaumelle +5
Recent advances in electron microscopy have enabled the imaging of single cells in 3D at nanometer length scale resolutions. An uncharted frontier for in silico biology is the abil…
q-bio.MN2016
Shear-Induced Nitric Oxide Production by Endothelial Cells
Krishna Sriram, Justin G. Laughlin, Padmini Rangamani +1
We present a biochemical model of the wall shear stress (WSS)-induced activation of endothelial nitric oxide synthase (eNOS) in an endothelial cell (EC). The model includes three k…