144 citations · 260 across the 5 of their papers we have counts for
5 papers
Spatial modeling algorithms for reactions and transport (SMART) in biological cells
Emmet A. Francis, Justin G. Laughlin, Jørgen S. Dokken +4
Biological cells rely on precise spatiotemporal coordination of biochemical reactions to control their many functions. Such cell signaling networks have been a common focus for mat…
SMART: Spatial Modeling Algorithms for Reaction and Transport
Justin G. Laughlin, Jørgen S. Dokken, Henrik N. T. Finsberg +4
Recent advances in microscopy and 3D reconstruction methods have allowed for characterization of cellular morphology in unprecedented detail, including the irregular geometries of…
An Open Source Mesh Generation Platform for Biophysical Modeling Using Realistic Cellular Geometries
Christopher T. Lee, Justin G. Laughlin, John B. Moody +4
Advances in imaging methods such as electron microscopy, tomography and other modalities are enabling high-resolution reconstructions of cellular and organelle geometries. Such adv…
3D mesh processing using GAMer 2 to enable reaction-diffusion simulations in realistic cellular geometries
Christopher T. Lee, Justin G. Laughlin, Nils Angliviel de La Beaumelle +5
Recent advances in electron microscopy have enabled the imaging of single cells in 3D at nanometer length scale resolutions. An uncharted frontier for in silico biology is the abil…
Shear-Induced Nitric Oxide Production by Endothelial Cells
Krishna Sriram, Justin G. Laughlin, Padmini Rangamani +1
We present a biochemical model of the wall shear stress (WSS)-induced activation of endothelial nitric oxide synthase (eNOS) in an endothelial cell (EC). The model includes three k…