2 papers
cs.LG2025
Classification of autoimmune diseases from Peripheral blood TCR repertoires by multimodal multi-instance learning
Ruihao Zhang, Mao chen, Fei Ye +3
T cell receptor (TCR) repertoires encode critical immunological signatures for autoimmune diseases, yet their clinical application remains limited by sequence sparsity and low witn…
cs.CE2025
LSMTCR: A Scalable Multi-Architecture Model for Epitope-Specific T Cell Receptor de novo Design
Ruihao Zhang, Xiao Liu
Designing full-length, epitope-specific TCR α\b{eta} remains challenging due to vast sequence space, data biases and incomplete modeling of immunogenetic constraints. We present L…