5 papers
Large Neighborhood and Hybrid Genetic Search for Inventory Routing Problems
Jingyi Zhao, Claudia Archetti, Tuan Anh Pham +1
The inventory routing problem (IRP) focuses on jointly optimizing inventory and distribution operations from a supplier to retailers over multiple days. Compared to other problems…
Extraction of energy from a black hole in Einstein-Maxwell-scalar theory
Cheng-Yong Zhang, Zehong Zhang, Ruifeng Zheng
Recently, it has been discovered that the nonlinear self-interaction of matter can induce energy extraction from black holes beyond superradiant instability. This process is closel…
A Deep Generative Model for the Design of Synthesizable Ionizable Lipids
Yuxuan Ou, Jingyi Zhao, Austin Tripp +2
Lipid nanoparticles (LNPs) are vital in modern biomedicine, enabling the effective delivery of mRNA for vaccines and therapies by protecting it from rapid degradation. Among the co…
Generative Model for Synthesizing Ionizable Lipids: A Monte Carlo Tree Search Approach
Jingyi Zhao, Yuxuan Ou, Austin Tripp +2
Ionizable lipids are essential in developing lipid nanoparticles (LNPs) for effective messenger RNA (mRNA) delivery. While traditional methods for designing new ionizable lipids ar…
Large data global existence for coupled massive-massless wave-type systems
Yuan Cai, Shijie Dong, Kuijie Li +1
We consider 3D Klein-Gordon-Zakharov (KGZ) and Dirac-Klein-Gordon (DKG) systems, where a common feature is that there exist both massless and massive fields in each system. We esta…