5 papers
Flexible Cancer-Associated Chromatin Configuration (CACC) Might Be the Fundamental Reason Why Cancer Is So Difficult to Cure
Gao-De Li
We once proposed that cell-type-associated chromatin configurations determine cell types and that cancer cell type is determined by cancer-associated chromatin configuration (CACC)…
Further Thoughts on Abnormal Chromatin Configuration and Oncogenesis
Gao-De Li
More than 30 years ago, we published a paper entitled as abnormal chromatin configuration and oncogenesis, which proposed the first hypothesis that links oncogenesis to abnormal th…
Nucleus may be the key site of chloroquine antimalarial action and resistance development
Gao-De Li
The first proposed hypothesis about the mechanism of chloroquine (CQ) action on malaria parasites is DNA intercalation hypothesis which indicates that the site of CQ action is with…
A Possible Mechanism of DNA to DNA Transcription in Eukaryotic Cells : Endonuclease Dependent Transcript Cutout
Gao-De Li
We previously proposed the existence of DNA to DNA transcription in eukaryotic cells, but the mechanism by which single-stranded DNA (ssDNA) transcript is produced and released fro…
Natural site-directed mutagenesis might exist in eukaryotic cells
Gao-De Li
Site-directed mutagenesis refers to a man-made molecular biology method that is used to make genetic alterations in the DNA sequence of a gene of interest. But based on our recentl…