494 citations · 2.3k across the 51 of their papers we have counts for
55 papers
Elasticity tunes mechanical stress localization around active topological defects
Lasse Bonn, Aleksandra Ardaševa, Amin Doostmohammadi
Mechanical stresses are increasingly found to be associated with various biological functionalities. At the same time, topological defects are being identified across a diverse ran…
Periodic orbits, pair nucleation, and unbinding of active nematic defects on cones
Farzan Vafa, David R. Nelson, Amin Doostmohammadi
Geometric confinement and topological constraints present promising means of controlling active materials. By combining analytical arguments derived from the Born-Oppenheimer appro…
Spontaneous Self-Constraint in Active Nematic Flows
Louise C. Head, Claire Dore, Ryan Keogh +5
Active processes drive and guide biological dynamics across scales -- from subcellular cytoskeletal remodelling, through tissue development in embryogenesis, to population-level ba…
Active topological defect absorption by a curvature singularity
Farzan Vafa, David R. Nelson, Amin Doostmohammadi
Using the Born-Oppenheimer approximation, we present a general description of topological defects dynamics in -atic materials on curved surfaces, and simplify it in the case of…
Spontaneous flows and dynamics of full-integer topological defects in polar active matter
Jonas Rønning, Julian Renaud, Amin Doostmohammadi +1
Polar active matter of self-propelled particles sustain spontaneous flows through the full-integer topological defects. We study theoretically the effect of both polar and dipolar…
Stress percolation criticality of glass to fluid transition in active cell layers
Siavash Monfared, Guruswami Ravichandran, Jose E. Andrade +1
Using three-dimensional representation of confluent cell layers, we map the amorphous solid to fluid phase transition in active cell layers onto the two-dimensional (2D) site perco…
Collective rotational motion of freely-expanding T84 epithelial cell colonies
Flora Ascione, Sergio Caserta, Speranza Esposito +6
Coordinated rotational motion is an intriguing, yet still elusive mode of collective cell migration, which is relevant in pathological and morphogenetic processes. Most of the stud…
Differential elasticity in lineage segregation of embryonic stem cells
Christine M. Ritter, Natascha Leijnse, Younes Farhangi Barooji +3
The question of what guides lineage segregation is central to development, where cellular differentiation leads to segregated cell populations destined for specialized functions. H…
Symmetry-restoring crossover from defect-free to defect-laden turbulence in polar active matter
Benjamin H. Andersen, Julian Renaud, Jonas Rønning +2
Coherent flows of self-propelled particles are characterized by vortices and jets that sustain chaotic flows, referred to as active turbulence. Here, we reveal a crossover between…
Nematic order condensation and topological defects in inertial active nematics
Roozbeh Saghatchi, Mehmet Yildiz, Amin Doostmohammadi
Living materials at different length scales manifest active nematic features such as orientational order, nematic topological defects, and active nematic turbulence. Using numerica…
Self-sustained oscillations of active viscoelastic matter
Emmanuel L. C. VI M. Plan, Huong Le Thi, Julia M. Yeomans +1
Models of active nematics in biological systems normally require complexity arising from the hydrodynamics involved at the microscopic level as well as the viscoelastic nature of t…
Distinct impacts of polar and nematic self-propulsion on active unjamming
Varun Venkatesh, Chandana Mondal, Amin Doostmohammadi
Though jamming transitions are long studied in condensed matter physics and granular systems, much less is known about active jamming (or unjamming), which commonly takes place in…
Bridging microscopic cell dynamics to nematohydrodynamics of cell monolayers
Aleksandra Ardaševa, Romain Mueller, Amin Doostmohammadi
It is increasingly being realized that liquid-crystalline features can play an important role in the properties and dynamics of cell monolayers. Here, we present a cell-based model…
Fluctuation-induced dynamics of nematic topological defects
Lasse Bonn, Aleksandra Ardaseva, Romain Mueller +2
Topological defects are increasingly being identified in various biological systems, where their characteristic flow fields and stress patterns are associated with continuous activ…
Quadrupolar active stress induces exotic phases of defect motion in active nematics
Salik A. Sultan, Mehrana R. Nejad, Amin Doostmohammadi
A wide range of living and artificial active matter exists in close contact with substrates and under strong confinement, where in addition to dipolar active stresses, quadrupolar…
Filopodia rotate and coil by actively generating twist in their actin shaft
Natascha Leijnse, Younes Farhangi Barooji, Mohammad Reza Arastoo +9
Filopodia are actin-rich structures, present on the surface of practically every known eukaryotic cell. These structures play a pivotal role in specific cell-cell and cell-matrix i…
Mechanics of cell integration in vivo
Guilherme B. Ventura, Aboutaleb Amiri, Raghavan Thiagarajan +3
During embryonic development, regeneration and homeostasis, cells have to physically integrate into their target tissues, where they ultimately execute their function. Despite a si…
Activity-induced instabilities of brain organoids
Kristian Thijssen, Guido L. A. Kusters, Amin Doostmohammadi
We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to e…
Physics of liquid crystals in cell biology
Amin Doostmohammadi, Benoit Ladoux
The last decade has witnessed a rapid growth in understanding of the pivotal roles of mechanical stresses and physical forces in cell biology. As a result an integrated view of cel…
Mechanical basis and topological routes to cell elimination
Siavash Monfared, Guruswami Ravichandran, Jose E. Andrade +1
Cell layers eliminate unwanted cells through the extrusion process, which underlines healthy versus flawed tissue behaviors. Although several biochemical pathways have been identif…
Half-integer and full-integer topological defects in polar active matter: Emergence, crossover, and coexistence
Aboutaleb Amiri, Romain Mueller, Amin Doostmohammadi
The presence and significance of active topological defects is increasingly realised in diverse biological and biomimetic systems. We introduce a continuum model of polar active ma…
Wrinkle force microscopy: a new machine learning based approach to predict cell mechanics from images
Honghan Li, Daiki Matsunaga, Tsubasa S. Matsui +4
Combining experiments with artificial intelligence algorithms, we propose a new machine learning based approach to extract the cellular force distributions from the microscope imag…
Phase field models of active matter
Romain Mueller, Amin Doostmohammadi
We present an overview of phase field modeling of active matter systems as a tool for capturing various aspects of complex and active interfaces. We first describe how interfaces b…
Activity pulses induce spontaneous flow reversals in viscoelastic environments
Emmanuel L. C. VI M. Plan, Julia M. Yeomans, Amin Doostmohammadi
Complex interactions between cellular systems and their surrounding extracellular matrices are emerging as important mechanical regulators of cell functions such as proliferation,…