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q-bio.GN2019
A Hybrid HMM Approach for the Dynamics of DNA Methylation
Charalampos Kyriakopoulos, Pascal Giehr, Alexander Lück +2
The understanding of mechanisms that control epigenetic changes is an important research area in modern functional biology. Epigenetic modifications such as DNA methylation are in…
q-bio.GN2017
A Stochastic Model for the Formation of Spatial Methylation Patterns
Alexander Lück, Pascal Giehr, Jörn Walter +1
DNA methylation is an epigenetic mechanism whose important role in development has been widely recognized. This epigenetic modification results in heritable changes in gene express…
q-bio.GN2016
H(O)TA: estimation of DNA methylation and hydroxylation levels and efficiencies from time course data
Charalampos Kyriakopoulos, Pascal Giehr, Verena Wolf
Methylation and hydroxylation of cytosines to form 5-methylcytosine (5mC) and 5-droxymethylcytosine (5hmC) belong to the most important epigenetic modifications and their vital rol…