3.1k citations · 7.1k across the 62 of their papers we have counts for
9 papers · 1 filter
Universal distribution of component frequencies in biological and technological systems
Tin Yau Pang, Sergei Maslov
Bacterial genomes and large-scale computer software projects both consist of a large number of components (genes or software packages) connected via a network of mutual dependencie…
Toolbox model of evolution of metabolic pathways on networks of arbitrary topology
Tin Yau Pang, Sergei Maslov
In prokaryotic genomes the number of transcriptional regulators is known to quadratically scale with the total number of protein-coding genes. Toolbox model was recently proposed t…
Toolbox model of evolution of prokaryotic metabolic networks and their regulation
Sergei Maslov, Sandeep Krishna, Tin Yau Pang +1
It has been reported that the number of transcription factors encoded in prokaryotic genomes scales approximately quadratically with their total number of genes. We propose a conce…
Fluctuations in Mass-Action Equilibrium of Protein Binding Networks
Koon-Kiu Yan, Dylan Walker, Sergei Maslov
We consider two types of fluctuations in the mass-action equilibrium in protein binding networks. The first type is driven by relatively slow changes in total concentrations (copy…
Propagation of large concentration changes in reversible protein binding networks
Sergei Maslov, I. Ispolatov
We study how the dynamic equilibrium of the reversible protein-protein binding network in yeast Saccharomyces cerevisiae responds to large changes in abundances of individual prote…
Detection of the dominant direction of information flow in densely interconnected regulatory networks
I. Ispolatov, Sergei Maslov
Finding the dominant direction of flow of information in densely interconnected regulatory or signaling networks is required in many applications in computational biology and neuro…
UV-induced mutagenesis in Escherichia coli SOS response: A quantitative model
Sandeep Krishna, Sergei Maslov, Kim Sneppen
Escherichia coli bacteria respond to DNA damage by a highly orchestrated series of events known as the SOS response, regulated by transcription factors, protein-protein binding and…
Propagation of fluctuations in interaction networks governed by the law of mass action
Sergei Maslov, Kim Sneppen, Iaroslav Ispolatov
Using an example of physical interactions between proteins, we study how perturbations propagate in interconnected networks whose equilibrium state is governed by the law of mass a…
Upstream Plasticity and Downstream Robustness in Evolution of Molecular Networks
Sergei Maslov, Kim Sneppen, Kasper Astrup Eriksen
Evolving biomolecular networks have to combine the stability against perturbations with flexibility allowing their constituents to assume new roles in the cell. Gene duplication fo…