289 citations · 619 across the 7 of their papers we have counts for
7 papers
Genome wide signals of pervasive positive selection in human evolution
David Enard, Philipp W. Messer, Dmitri Petrov
The role of positive selection in human evolution remains controversial. On the one hand, scans for positive selection have identified hundreds of candidate loci and the genome-wid…
Recent selective sweeps in North American Drosophila melanogaster show signatures of soft sweeps
Nandita R. Garud, Philipp W. Messer, Erkan O. Buzbas +1
Rapid adaptation has been observed in numerous organisms in response to selective pressures, such as the application of pesticides and the presence of pathogens. When rapid adaptat…
Strong Purifying Selection at Synonymous Sites in D. melanogaster
David S. Lawrie, Philipp W. Messer, Ruth Hershberg +1
Synonymous sites are generally assumed to be subject to weak selective constraint. For this reason, they are often neglected as a possible source of important functional variation.…
SLiM: Simulating Evolution with Selection and Linkage
Philipp W. Messer
SLiM is an efficient forward population genetic simulation designed for studying the effects of linkage and selection on a chromosome-wide scale. The program can incorporate comple…
The McDonald-Kreitman Test and its Extensions under Frequent Adaptation: Problems and Solutions
Philipp W. Messer, Dmitri A. Petrov
Population genomic studies have shown that genetic draft and background selection can profoundly affect the genome-wide patterns of molecular variation. We performed forward simula…
Estimating the Strength of Selective Sweeps from Deep Population Diversity Data
Philipp W. Messer, Richard A. Neher
Selective sweeps are typically associated with a local reduction of genetic diversity around the adaptive site. However, selective sweeps can also quickly carry neutral mutations t…