259 citations · 1.2k across the 21 of their papers we have counts for
23 papers
Interplay between substrate rigidity and tissue fluidity regulates cell monolayer spreading
Michael F. Staddon, Michael P. Murrell, Shiladitya Banerjee
Coordinated and cooperative motion of cells is essential for embryonic development, tissue morphogenesis, wound healing and cancer invasion. A predictive understanding of the emerg…
Cellular resource allocation strategies for cell size and shape control in bacteria
Diana Serbanescu, Nikola Ojkic, Shiladitya Banerjee
Bacteria are highly adaptive microorganisms that thrive in a wide range of growth conditions via changes in cell morphologies and macromolecular composition. How bacterial morpholo…
Size-regulated symmetry breaking in reaction-diffusion models of developmental transitions
Jake Cornwall Scoones, Deb Sankar Banerjee, Shiladitya Banerjee
The development of multicellular organisms proceeds through a series of morphogenetic and cell-state transitions, transforming homogeneous zygotes into complex adults by a process…
Single-cell approaches to cell competition: high-throughput imaging, machine learning and simulations
Daniel Gradeci, Anna Bove, Guillaume Charras +2
Cell competition is a quality control mechanism in tissues that results in the elimination of less fit cells. Over the past decade, the phenomenon of cell competition has been iden…
Cooperation of dual modes of cell motility promotes epithelial stress relaxation to accelerate wound healing
Michael F. Staddon, Dapeng Bi, A. Pasha Tabatabai +3
Collective cell migration in cohesive units is vital for tissue morphogenesis, wound repair, and immune response. While the fundamental driving forces for collective cell motion st…
Epithelial Wound Healing Coordinates Distinct Actin Network Architectures to Conserve Mechanical Work and Balance Power
Visar Ajeti, A. Pasha Tabatabai, Andrew J. Fleszar +8
How cells with diverse morphologies and cytoskeletal architectures modulate their mechanical behaviors to drive robust collective motion within tissues is poorly understood. During…
Continuum models of collective cell migration
Shiladitya Banerjee, M. Cristina Marchetti
Collective cell migration plays a central role in tissue development, morphogenesis, wound repair and cancer progression. With the growing realization that physical forces mediate…
Entropy Production Rate is Maximized in Non-Contractile Actomyosin
Daniel S. Seara, Vikrant Yadav, Ian Linsmeier +5
The actin cytoskeleton is an active semi-flexible polymer network whose non-equilibrium properties coordinate both stable and contractile behaviors to maintain or change cell shape…
Design principles for selective self-assembly of active networks
Simon L. Freedman, Glen M. Hocky, Shiladitya Banerjee +1
Living cells dynamically modulate the local morphologies of their actin cytoskeletons to perform biological functions, including force transduction, intracellular transport, and ce…
A versatile framework for simulating the dynamic mechanical structure of cytoskeletal networks
Simon L. Freedman, Shiladitya Banerjee, Glen M. Hocky +1
Computer simulations can aid in understanding how collective materials properties emerge from interactions between simple constituents. Here, we introduce a coarse-grained model th…
Shape dynamics of growing cell walls
Shiladitya Banerjee, Norbert F. Scherer, Aaron R. Dinner
We introduce a general theoretical framework to study the shape dynamics of actively growing and remodeling surfaces. Using this framework we develop a physical model for growing b…
Intergenerational continuity of cell shape dynamics in Caulobacter crescentus
Charles S. Wright, Shiladitya Banerjee, Srividya Iyer-Biswas +3
We investigate the intergenerational shape dynamics of single Caulobacter crescentus cells using a novel combination of imaging techniques and theoretical modeling. We determine th…
Propagating stress waves during epithelial expansion
Shiladitya Banerjee, Kazage J. C. Utuje, M. Cristina Marchetti
Coordinated motion of cell monolayers during epithelial wound healing and tissue morphogenesis involves mechanical stress generation. Here we propose a model for the dynamics of ep…
Optimal shapes and stresses of adherent cells on patterned substrates
Shiladitya Banerjee, Rastko Sknepnek, M. Cristina Marchetti
We investigate a continuum mechanical model for an adherent cell on two dimensional adhesive micropatterned substrates. The cell is modeled as an isotropic and homogeneous elastic…
Controlling cell-matrix traction forces by extracellular geometry
Shiladitya Banerjee, M. Cristina Marchetti
We present a minimal continuum model of strongly adhering cells as active contractile isotropic media and use the model to study the effect of the geometry of the adhesion patch in…
Cadherin-Based Intercellular Adhesions Organize Epithelial Cell-Matrix Traction Forces
Aaron F. Mertz, Yonglu Che, Shiladitya Banerjee +6
Cell--cell and cell-matrix adhesions play essential roles in the function of tissues. There is growing evidence for the importance of crosstalk between these two adhesion types, ye…
Polymorphism and bistability in adherent cells
Shiladitya Banerjee, Luca Giomi
The optimal shapes attained by contractile cells on adhesive substrates are determined by the interplay between intracellular forces and adhesion with the extracellular matrix. We…
Contractile stresses in cohesive cell layers on finite-thickness substrates
Shiladitya Banerjee, M. Cristina Marchetti
Using a minimal model of cells or cohesive cell layers as continuum active elastic media, we examine the effect of substrate thickness and stiffness on traction forces exerted by s…
Scaling of Traction Forces with Size of Cohesive Cell Colonies
Aaron F. Mertz, Shiladitya Banerjee, Yonglu Che +6
To understand how the mechanical properties of tissues emerge from interactions of multiple cells, we measure traction stresses of cohesive colonies of 1-27 cells adherent to soft…
Generic phases of cross-linked active gels: Relaxation, Oscillation and Contractility
Shiladitya Banerjee, Tanniemola B. Liverpool, M. Cristina Marchetti
We study analytically and numerically a generic continuum model of an isotropic active solid with internal stresses generated by non-equilibrium `active' mechano-chemical reactions…
Substrate rigidity deforms and polarizes active gels
Shiladitya Banerjee, M. Cristina Marchetti
We present a continuum model of the coupling between cells and substrate that accounts for some of the observed substrate-stiffness dependence of cell properties. The cell is model…
Motor-driven Dynamics of Cytoskeletal FIlaments in Motility Assays
Shiladitya Banerjee, M. Cristina Marchetti, Kristian Müller-Nedebock
We model analytically the dynamics of a cytoskeletal filament in a motility assay. The filament is described as rigid rod free to slide in two dimensions. The motor proteins consis…
Instabilities and Oscillations in Isotropic Active Gels
Shiladitya Banerjee, M. Cristina Marchetti
We present a generic formulation of the continuum elasticity of an isotropic crosslinked active gel. The gel is described by a two-component model consisting of an elastic network…