22 citations · 28 across the 5 of their papers we have counts for
3 papers · 1 filter
A Weighted Exact Test for Mutually Exclusive Mutations in Cancer
Mark D. M. Leiserson, Matthew A. Reyna, Benjamin J. Raphael
The somatic mutations in the pathways that drive cancer development tend to be mutually exclusive across tumors, providing a signal for distinguishing driver mutations from a large…
CoMEt: A Statistical Approach to Identify Combinations of Mutually Exclusive Alterations in Cancer
Mark D. M. Leiserson, Hsin-Ta Wu, Fabio Vandin +1
Cancer is a heterogeneous disease with different combinations of genetic and epigenetic alterations driving the development of cancer in different individuals. While these alterati…
Accurate Computation of Survival Statistics in Genome-wide Studies
Fabio Vandin, Alexandra Papoutsaki, Benjamin J. Raphael +1
A key challenge in genomics is to identify genetic variants that distinguish patients with different survival time following diagnosis or treatment. While the log-rank test is wide…