2 citations · 2 across the 2 of their papers we have counts for
3 papers
A Weighted Exact Test for Mutually Exclusive Mutations in Cancer
Mark D. M. Leiserson, Matthew A. Reyna, Benjamin J. Raphael
The somatic mutations in the pathways that drive cancer development tend to be mutually exclusive across tumors, providing a signal for distinguishing driver mutations from a large…
Multi-State Perfect Phylogeny Mixture Deconvolution and Applications to Cancer Sequencing
Mohammed El-Kebir, Gryte Satas, Layla Oesper +1
The reconstruction of phylogenetic trees from mixed populations has become important in the study of cancer evolution, as sequencing is often performed on bulk tumor tissue contain…
CoMEt: A Statistical Approach to Identify Combinations of Mutually Exclusive Alterations in Cancer
Mark D. M. Leiserson, Hsin-Ta Wu, Fabio Vandin +1
Cancer is a heterogeneous disease with different combinations of genetic and epigenetic alterations driving the development of cancer in different individuals. While these alterati…