4 papers
Robustness and fragility of Boolean models for genetic regulatory networks
Madalena Chaves, Reka Albert, Eduardo D. Sontag
Interactions between genes and gene products give rise to complex circuits that enable cells to process information and respond to external signals. Theoretical studies often descr…
Computation of amplification for systems arising from cellular signaling pathways
Eduardo D. Sontag, Madalena Chaves
A commonly employed measure of the signal amplification properties of an input/output system is its induced L2 norm, sometimes also known as "H infinity" gain. In general, however,…
Optimal length and signal amplification in weakly activated signal transduction cascades
Madalena Chaves, Eduardo D. Sontag, Robert J. Dinerstein
Weakly activated signaling cascades can be modeled as linear systems. The input-to-output transfer function and the internal gain of a linear system, provide natural measures for t…
State-estimators for chemical reaction networks of Feinberg-Horn-Jackson zero deficiency type
Madalena Chaves, Eduardo D. Sontag
One of the most interesting questions in control theory is that of constructing observers. Observers compute estimates of the internal states of a dynamical system, using data prov…