3 citations · 4 across the 7 of their papers we have counts for
7 papers
Shape, size and robustness: feasible regions in the parameter space of biochemical networks
Madalena Chave, Eduardo D. Sontag, Anirvan M. Sengupta
The concept of robustness of regulatory networks has been closely related to the nature of the interactions among genes, and the capability of pattern maintenance or reproducibilit…
Bistability preserving model reduction in apoptosis
Steffen Waldherr, Thomas Eissing, Madalena Chaves +1
Biological systems are typically very complex and need to be reduced before they are amenable to a thorough analysis. Also, they often possess functionally important dynamic featur…
Methods of robustness analysis for Boolean models of gene control networks
Madalena Chaves, Eduardo D. Sontag, Reka Albert
As a discrete approach to genetic regulatory networks, Boolean models provide an essential qualitative description of the structure of interactions among genes and proteins. Boolea…
Robustness and fragility of Boolean models for genetic regulatory networks
Madalena Chaves, Reka Albert, Eduardo D. Sontag
Interactions between genes and gene products give rise to complex circuits that enable cells to process information and respond to external signals. Theoretical studies often descr…
Computation of amplification for systems arising from cellular signaling pathways
Eduardo D. Sontag, Madalena Chaves
A commonly employed measure of the signal amplification properties of an input/output system is its induced L2 norm, sometimes also known as "H infinity" gain. In general, however,…
Optimal length and signal amplification in weakly activated signal transduction cascades
Madalena Chaves, Eduardo D. Sontag, Robert J. Dinerstein
Weakly activated signaling cascades can be modeled as linear systems. The input-to-output transfer function and the internal gain of a linear system, provide natural measures for t…