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physics.med-ph2019
Error reduction in biosensors using secondary labeling
Tuhin Chakrabortty, Manoj M Varma
In this article, we derive the limit of detection for a two-step molecular recognition process and show that in-spite of all the recognition reactions being in equilibrium the over…
physics.med-ph2019
Fundamental Limitations in Biomarker Based Early Disease Diagnosis
Tuhin Chakrabortty, Chandra R. Murthy, Manoj Varma
Clinical biosensors with low detection limit hold significant promise in the early diagnosis of debilitating diseases. Recent progress in sensor development has led to the demonstr…