205 citations · 361 across the 13 of their papers we have counts for
15 papers
Epigenetic factor competition reshapes the EMT landscape
M. Ali Al-Radhawi, Shubham Tripathi, Yun Zhang +2
The emergence of and transitions between distinct phenotypes in isogenic cells can be attributed to the intricate interplay of epigenetic marks, external signals, and gene regulato…
Towards decoding the coupled decision-making of metabolism and epithelial-mesenchymal transition in cancer
Dongya Jia, Jun Hyoung Park, Harsimran Kaur +9
Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis. During metastasis, a developmental program known as the epithelial-mesenchymal tr…
Decoding the mechanisms underlying cell-fate decision-making during stem cell differentiation by Random Circuit Perturbation
Bin Huang, Mingyang Lu, Madeline Galbraith +3
Stem cells can precisely and robustly undergo cellular differentiation and lineage commitment, referred to as stemness. However, how the gene network underlying stemness regulation…
Leader-cell-driven epithelial sheet fingering
Yanjun Yang, Herbert Levine
Collective cell migration is crucial in many biological processes such as wound healing, tissue morphogenesis, and tumor progression. The leading front of a collective migrating ep…
Physics Approaches to the Spatial Distribution of Immune Cells in Tumors
Clare C. Yu, Juliana C. Wortman, Ting-Fang He +12
The goal of immunotherapy is to enhance the ability of the immune system to kill cancer cells. Immunotherapy is more effective and, in general, the prognosis is better, when more i…
Biological Regulatory Networks are Minimally Frustrated
Shubham Tripathi, David A. Kessler, Herbert Levine
Characterization of the differences between biological and random networks can reveal the design principles that enable the robust realization of crucial biological functions inclu…